Objective: This study aimed to study the changes of active components in irradiated Rhodiola rosea extracts (RRE) and their hypoglycemic effect. Methods: Rhodiola rosea was irradiated with 60Co-γ rays at doses of 5, 10, 20 and 30 kGy, respectively. High performance liquid chromatography (HPLC) was used to analyze RRE compounds before (0 kGy) and after irradiation. The type 1 diabetic mouse models established by intraperitoneal injection of Streptozotocin (STZ) were given a gavage. The body weight, fasting blood glucose, food intake and water intake of mice were measured regularly. Oral glucose tolerance was measured on the last day, after dissection, organ coefficient, serum total cholesterol (TC), glycosylated hemoglobin (GHb), total triglyceride (TG), malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) were measured. Results: The content of salidroside in RRE was significantly decreased after irradiation (P<0.05), and the content of loxavir was significantly increased at 5, 10 and 20 kGy (P<0.05). Tyrosol was detected at 20 kGy. Compared with the model group, the body weight of mice was given a gavage with irradiation RRE was increased, the food intake, water intake and blood glucose level decreased, and the food utilization rate increased significantly (P<0.05). The levels of TC, GHb, TG and MDA were significantly decreased (P<0.05), while the activities of SOD and CAT were significantly increased (P<0.05). The phenomenon of organ swelling was improved, and the effect was better at 20 kGy, and there was a significant difference with other irradiation doses (P<0.05). Conclusion: The composition and content of RRE compounds changed after irradiation, and RRE can reduce the level of diabetes in type 1 diabetic mice before and after irradiation. The irradiation dose of 20 kGy is effective.

Publication Date


First Page


Last Page





[1] 郭飞.研究临床糖尿病诊断中常规检验和生化检验的应用价值[J].名医,2018(8):108.GUO F.To study the application value of routine tests and biochemical tests in clinical diabetes diagnosis[J].Famous Doctor,2018(8):108.
[2] 杨中策,董林涛,潘俐,等.中国暴发1型糖尿病患者临床特点的Meta分析[J].中国循证医学杂志,2022,22(8):891-895.YANG Z C,DONG L T,PAN L,et al.Clinical characteristics of Chinese patients with fulminant type 1 diabetes mellitus:A meta-analysis[J].Chinese Journal of Evidence-Based Medicine,2022,22(8):891-895.
[3] 陈换换,张小莉,宋超杰,等.以肠道菌群为靶点防治1型糖尿病的研究进展[J].现代免疫学,2022,42(5):434-440.CHEN H H,ZHANG X L,SHONG C J,et al.Advances in the prevention and treatment of type 1 diabetes mellitus by targeting intestinal microbiota[J].Current Immunology,2022,42(5):434-440.
[4] 郭文情.糖尿病患者药物治疗不良反应发生情况分析[J].继续医学教育,2022,36(1):133-136.GOU W Q.Analysis on the occurrence of adverse drug reactions in diabetic patients[J].Continuing Medical Education,2022,36(1):133-136.
[5] 任卫合,罗龙龙,蔡林海,等.红景天抗缺氧损伤作用的研究进展[J].中成药,2022,44(9):2 911-2 916.REN W H,LUO L L,CAI L H,et al.Progress in the anti-hypoxic damage effects of Rhodiola rosea[J].Chinese Traditional Patent Medicine,2022,44(9):2 911-2 916.
[6] 李永盛,费秀兰,刘永峰,等.西藏红景天中活性成分含量的影响因素分析[J].食品工业,2019,40(10):186-191.LI Y S,FEI X L,LIU Y F,et al.Analysis of factors affecting the content of active compounds in Tibet Rhodiola[J].The Food Industry,2019,40(10):186-191.
[7] 杨泽霖,黄鑫,刘俊杰,等.红景天苷调控PI3K/Akt信号通路对LPS诱导的BV2小胶质细胞的抗炎作用[J].中国药理学通报,2019,35(8):1 145-1 149.YANG Z L,HUANG X,LIU J J,et al.Anti-inflammatory effects of salidroside on LPS-induced BV2 microglia cells via P13K/Akt signaling pathway[J].Chinese Pharmacological Bulletin,2019,35(8):1 145-1 149.
[8] 张立超,王晨宇,曹慧芳,等.红景天苷对梗阻性黄疸大鼠的肝保护作用及机制探讨[J].山东医药,2015,55(46):32-33.ZHANG L C,WANG C Y,CAO H F,et al.Liver protective effect of salidroside on obstructive jaundice in rats and its mechanism[J].Shandong Medical Journal,2015,55(46):32-33.
[9] 孙熙浛,齐欣,崔承弼.辐照红景天乙醇提取物的抗氧化作用及美白作用研究[J].食品工业科技,2020,41(23):325-331.SUN X H,QI X,CUI C B.Antioxidant and whitening effects of ethanol extract from irradiated Rhodiola rosea[J].Science and Technology of Food Industry,2020,41(23):325-331.
[10] 朴成浩.辐照处理长白山红景天抗氧化和抗疲劳作用研究[D].延吉:延边大学,2020:27.PIAO C H.Study on Anti-oxidation and anti-fatigue of Rhodiola rosea in changbai mountain by irradiation[D].Yanji:Yanbian University,2020:27.
[11] 林晓月,孙新.红景天抗衰老作用机制研究进展[J].中国老年学杂志,2018,38(13):3 299-3 300.LIN X Y,SUN X.Research progress on anti-aging mechanism of Rhodiola rosea[J].Chinese Journal of Gerontology,2018,38(13):3 299-3 300.
[12] 鞠霖杰,温小花,舒娈.红景天苷对胰岛β细胞保护作用研究及机制探讨[J].南京中医药大学学报,2016,32(5):456-460.JIU L J,WEN X H,SHU L.Study on protective effects of salidrosides on pancreatic β-cell survival[J].Journal of Nanjing University of Chinese Medicine,2016,32(5):456-460.
[13] KIM S H,HYUN S H,CHOUNG S Y.Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice[J].Biofactors,2010,26(3):209-219.
[14] 邓超,邹朝晖.辐照对食品营养成分的影响研究[J].食品安全导刊,2022(2):128-130.DENG C,ZHOU C H.Study on the effect of irradiation on the nutrient composition of food[J].China Food Safety Magazine,2022(2):128-130.
[15] 耿建暖.食品辐照技术及其食品中的应用[J].食品研究与开发,2013,34(15):109-112.GENG J N.Food irradiation and its application in food processing[J].Food Research and Development,2013,34(15):109-112.
[16] 齐仕博,张露,宋鑫萍,等.辐照对人参活性成分及其药理特性的影响研究进展[J].食品与机械,2018,34(11):161-166,199.QI S B,ZHANG L,SONG X P,et al.Research progress on the influence of irradiation on ginseng active components and pharmacological properties[J].Food & Machinery,2018,34(11):161-166,199.
[17] PESCHEL W,KUMP A,HORVTH A,et al.Age and harvest season affect the phenylpropenoid content in cultivated European Rhodiola rosea L.[J].Industrial Crops and Products,2016,83:787-802.
[18] 张露,姜欣,金莉英,等.辐照处理对桦褐孔菌多糖降血糖作用的影响[J].食品与机械,2020,36(11):143-147.ZHANG L,JIANG X,JIN L Y,et al.Effect of irradiation on the hypoglycemic effect of polysaccharide from Foramen betulaeformis[J].Food & Machinery,2020,36(11):143-147.
[19] 刘素欣,张露,崔承弼.红景天提取物的降血糖作用研究[J].延边大学农学学报,2020,42(2):21-26.LIU S X,ZHANG L,CUI C B.Study on the hypoglycemic effect of Rhodiola Rosea extract[J].Journal of Agricultural Science Yanbian University,2020,42(2):21-26.
[20] 王磊,刘玮.自拟大黄水蛭合剂对糖尿病患者TG、TC、LDL-C和HDL-C的影响[J].河北医药,2016,38(24):3 776-3 778.WANG L,LIU W.Effect of self-made Rhubarb leech mixture on TG,TC,LDL-C and HDL-C in diabetic patients[J].Hebei Medical Journal,2016,38(24):3 776-3 778.
[21] 张泽鹏,徐兴军,刘佳人,等.牡荆素对1型糖尿病小鼠体内抗氧化酶活性及相关基因表达的影响[J].天然产物研究与开发,2022,34(4):623-629.ZHANG Z P,XU X J,LIU J R,et al.Effects of vitexin on activity of antioxidant enzymes and expression of related genes in type 1 diabetic mice[J].Natural Product Research and Development,2022,34(4):623-629.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.