Abstract
The approved health food products in China were analyzed from the following five aspects: the number of approved products, the use of raw materials, the claim of health function, the distribution of dosage forms, and the index of signature ingredients. It was found that almost all Spirulina powder was the primary processed product, and the homogeneity was serious. Moreover, the characteristic components were different from those of β-carotene and phycocyanin specified in the record. Based on these problems, the healthy development of health food industry should be promoted by broadening the idea of product research and development, and then improve the synergistic effect of registration and filing.
Publication Date
10-16-2022
First Page
1
Last Page
6,13
DOI
10.13652/j.spjx.1003.5788.2022.60070
Recommended Citation
Yu, FU; Yu, JIANG; Jin-bo, WANG; Bo-jin, ZHANG; Chen, SONG; and Ming-xia, SUN
(2022)
"Approved situation and problems of the Spirulina health foods,"
Food and Machinery: Vol. 38:
Iss.
8, Article 1.
DOI: 10.13652/j.spjx.1003.5788.2022.60070
Available at:
https://www.ifoodmm.cn/journal/vol38/iss8/1
References
[1] 魏艳丽,姜国庆,彭坚,等.螺旋藻的营养健康功能及在食品中应用研究进展[J].食品工业科技,2022,43(8):406-415.WEI Y L,JIANG G Q,PENG J,et al.A review of nutrition and health functions of Spirulina and its application in food industry[J].Science and Technology of Food Industry,2022,43(8):406-415.
[2] 陈宇熹,阴浩,谢雯婷,等.我国螺旋藻产业面临的困境与发展思路[J].智慧农业导刊,2021,1(16):15-17.CHEN Y X,YIN H,XIE W T,et al.Spirulina industry in China:Dilemmas and development paths[J].Journal of Smart Agriculture,2021,1(16):15-17.
[3] JUNG F,KRUGER-GENGE A,WALDECKC P,et al.Spirulina platensis,a super food?[J].Journal of Cellular Biotechnology,2019,5(1):43-54.
[4] 王娜,向清豪,赵肖荣,等.螺旋藻全蛋白与家族分类[J].食品科学,2018,39(16):201-207.WANG N,XIANG Q H,ZHAO X R,et al.Family classification of the whole proteins of Spirulina[J].Food Science,2018,39(16):201-207.
[5] 刘灵杰,陈卫卫,梁迪,等.螺旋藻营养保健作用及脱腥味的研究进展[J].中国实验方剂学杂志,2017,23(2):213-219.LIU L J,CHEN W W,LIANG D,et al.Review on removing alage smell nutrition and health action of Spirulina[J].Chinese Journal of Experimental Formulas,2017,23(2):213-219.
[6] 闫春宇,王素英,董世瑞.22株螺旋藻(节旋藻)氨基酸成分分析及营养评价[J].食品与机械,2015,31(6):21-27.YAN C Y,WANG S Y,DONG S R.Analysis of amino acid composition and nutritional evaluation of 22 Spirulina(Athrospira)strains[J].Food & Machinery,2015,31(6):21-27.
[7] 吴彦,丁华.螺旋藻联合使用研究进展[J].海峡药学,2013,25(8):20-23.WU Y,DING H.Research progress on the use of Spirulina[J].Strait Pharmacy,2013,25(8):20-23.
[8] LUNDIN H.On the occurrence of vitamins in marine algae[M].New York:Proc Int Seaweed Symp,1956:39-40.
[9] 华永有.高效液相色谱法测定螺旋藻中维生素B1[J].中国预防医学杂志,2015,16(3):222-225.HUA Y Y.High performance liquid chromatography method for determination of vitamins B1 in Spirulina[J].Chinese Preventive Medicine,2015,16(3):222-225.
[10] 华永有.螺旋藻类保健食品中核黄素的检测方法研究[J].海峡预防医学杂志,2014,20(5):50-51.HUA Y Y.Study on the detection method of riboflavin in Spirulina health food[J].Strait Journal of Preventive Medicine,2014,20(5):50-51.
[11] 王菲,佘星星,孙冰洁,等.螺旋藻γ-亚麻酸的提取优化及体外抗氧化活性的研究[J].食品工业科技,2014,35(19):68-72.WANG F,SHE X X,SUN B J,et al.Study on the optimized extraction and in vitro antioxidant activities of γ-Linolenic acid from Spirulina platensis[J].Science and Technology of Food Industry,2014,35(19):68-72.
[12] 胡晓炜.气相色谱法测定螺旋藻片γ-亚麻酸含量及其测定不确定度分析[J].医药导报,2007,26(11):1 364-1 366.HU X W.Determination of γ-linolenic acid content in Spirulina tablets by gas chromatography and analysis of its uncertainty[J].Heraldof Medicine,2007,26(11):1 364-1 366.
[13] 方蕙.基于光谱技术对钝顶螺旋藻藻蓝蛋白含量的快速检测研究[D].杭州:浙江大学,2020:70.FANG H.The research of rapid determination of phycocyanin in Spirulina platensis based of spectroscopic techniques[D].Hangzhou:Zhejiang University,2020:70.
[14] 王雪莹.三相萃取法在藻蓝蛋白分离纯化中的应用[D].哈尔滨:哈尔滨工业大学,2021:53.WANG X Y.Application of three-phase partitioning in purification of C-phycocyanin[D].Harbin:Harbin Institute of Technology,2021:53.
[15] 王林,朱惠贤,章新,等.高效液相色谱法测定螺旋藻中几种色素的研究[J].特产研究,2005(2):57-60.WANG L,ZHU H X,ZHANG X,et al.Study on determination of pigments in Springer by high performance liquid chromatography[J].Special Wild Economic Animal and Plant Research,2005(2):57-60.
[16] 张亚旗,卢珍华,黄世英,等.钝顶螺旋藻多糖的提取工艺及其生物活性[J].集美大学学报(自然科学版),2020,25(6):420-429.ZHANG Y Q,LU Z H,HUANG S Y,et al.Extraction technology and bioactivity of polysaccharide from Spirulina platensis[J].Journal of Jimei University(Natural Science),2020,25(6):420-429.
[17] 王群,陈诗科,李浩尧,等.螺旋藻多糖提取纯化及其抗结肠腺癌活性评价[J].食品与机械,2016,32(6):151-155.WANG Q,CHEN S K,LI H Y,et al.Extraction and purification of polysaccharide from Spirulina and its anti-colonic adenocarcinoma capacity[J].Food & Machinery,2016,32(6):151-155.
[18] 张喜峰,张芬琴,杨生辉,等.超声集成乙醇/正丁醇双水相萃取螺旋藻中的β-胡萝卜素[J].食品工业科技,2015,36(17):187-191.ZHANG X F,ZHANG F Q,YANG S H,et al.Ethanol/n-butanol aqueous two-phase coupled with ultrasound for the extraction of β-carotene from Spirulina platensi[J].Science and Technology of Food Industry,2015,36(17):187-191.
[19] 李兵,赵海燕,刘伟,等.超高效合相色谱/二极管阵列检测器测定螺旋藻保健食品中的类胡萝卜素[J].分析测试学报,2015,34(7):813-818.LI B,ZHAO H Y,LIU W,et al.Rapid determination of carotenoids in Spirulina dietary supplement products by ultra performance convergence chromatography with photodiode array detector[J].Journal of Instrumental Analysis,2015,34(7):813-818.
[20] 杜鹏,张晓娜,董诗源.藻类保健食品研发状况及问题探讨[J].海峡预防医学杂志,2020,26(6):73-75.DU P,ZHANG X N,DONG S Y.Discussion on the development status and problems of algal health food[J].Strait Journal of Preventive Medicine,2020,26(6):73-75.
[21] 钟文洁,刘淑聪.保健食品注册及消费市场现状分析[J].中国药事,2016,30(11):1 056-1 062.ZHONG W,LIU S C.Situation analysis of health food registration and consumer market[J].China Pharmaceutical Affairs,2016,30(11):1 056-1 062.
[22] 国家市场监督管理总局,国家卫生健康委员会,国家中医药管理局.《关于发布辅酶Q10等五种保健食品原料目录的公告》(2020年第54号)[EB/OL].(2020-12-01)[2022-06-08].http://gkml.samr.gov.cn/nsjg/tssps/202012/t20201201_324007.html.State Administration for Market Regulation,National Health Commission of the People’s Republic of China,National Administration of Traditional Chinese Medicine Administration.Announcement on releasing the catalogue of five raw materials for health food such as coenzyme Q10(No.54 of 2020)[EB/OL].(2020-12-01)[2021-10-08].http://gkml.samr.gov.cn/nsjg/tssps/202012/t20201201_324007.html.
[23] 国家市场监督管理总局.关于发布《辅酶Q10等五种保健食品原料备案产品剂型及技术要求》的公告[EB/OL].(2021-01-29)[2022-06-08].http://www.samr.gov.cn/tssps/tzgg/zjwh/202102/t20210201_325737.html.State Administration for Market Regulation.Announcement on releasing the dosage form and quality of five raw materials for health food such as coenzyme Q10[EB/OL].(2021-01-29)[2021-10-08].http://www.samr.gov.cn/tssps/tzgg/zjwh/202102/t20210201_325737.html.
[24] 中华人民共和国国家卫生健康委员会.关于将油菜花粉等食品新资源列为普通食品管理的公告[EB/OL].(2004-08-20)[2022-06-08].http://www.nhc.gov.cn/cms-search/xxgk/getManuscriptXxgk.htm?id=27105.National Health Commission of the People's Republic of China.Announcement on listing new food resources such as rape pollen as general food management[EB/OL].(2004-08-20)[2022-06-08].http://www.nhc.gov.cn/cms-search/xxgk/getManuscriptXxgk.htm?id=27105.
[25] 周月婵,胡怡秀,马征,等.螺旋藻干粉制剂辅助降血脂和调节免疫功能动物实验研究[J].实用预防医学,2006,13(2):300-303.ZHOU Y C,HU Y X,MA Z,et al.Animals study on Spirulina as an adjuvant blood lipid lowering and immune function enhancing agent[J].Practical Preventive Medicine,2006,13(2):300-303.
[26] 王文博.螺旋藻的生物活性成分分析及其免疫特性研究[D].呼和浩特:内蒙古农业大学,2009:45-46.WANG W B.Study on biological activities ingredients and immunological characteristics of Spirulina[D].Huhhot:Inner Mongolia Agricultural University,2009:45-46.
[27] 许娇红,张熠,杨秀静,等.螺旋藻多糖增强免疫力功能试验研究[J].海峡药学,2018,30(1):31-33.XU J H,ZHANG Y,YANG X J,et al.Experimental study on enhancing immunity of the Spirulina polysaccharides[J].Strait Pharmaceutical Journal,2018,30(1):31-33.
[28] 孔秀芹,戴伟民,葛海涛,等.螺旋藻来源的γ-亚麻酸甲酯调血脂作用研究[J].中国海洋药物,2003(6):30-34.KONG X Q,DAI W M,GE H T,et al.Studies on thehypolipidemic effects of gamma-linolenic acid methyl ester derived from Spirulina maxima[J].Chinese Marine Medicine,2003(6):30-34.
[29] SERBAN M,SAHEBKAR A,DRAGAN S,et al.A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations[J].Clinical Nutrition,2016,35(4):842-851.
[30] TORRES-DURAN P V,FERREIRAHERMOSILLO A,JUAREZOROPEZA M A.Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of mexican population:A preliminary report[J].Lipids in Health and Disease,2007,6(1):33.
[31] MANI U V,DESAI S,IYER U.Studies on the long-term effect of Spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients[J].Journal of Nutraceuticals Functional & Medical Foods,2000,2(3):25-32.
[32] 万小瑾,金磊.螺旋藻的抗疲劳作用研究[J].海峡药学,2010,22(11):7-9.WAN X J,JIN L.The Study of spirulina on the anti-fatigue effect[J].Strait Pharmaceutical Journal,2010,22(11):7-9.
[33] 王书全,李丽.螺旋藻多糖抗疲劳作用研究[J].食品工业科技,2013,34(22):328-330,334.WANG S Q,LI L.Study on anti-fatigue effect of Spirulina polysaccharide[J].Science and Technology of Food Industry,2013,34(22):328-330,334.
[34] 赵淑锐,郑美青,吴英婷,等.螺旋藻体外清除自由基的ESR研究[J].食品研究与开发,2015,36(18):91-94.ZHAO S R,ZHENG M Q,WU Y T,et al.Investigation with ESR on the radical scavenging effect of Spirulina in vitro[J].Food Research and Development,2015,36(18):91-94.
[35] THAAKUR S R,JYOTHI B.Effect of Spirulina maxima on the haloperidol induced tardive dyskinesia and oxidative stress in rats[J].Journal of Neural Transmission,2007,114(9):1 217-1 225.
[36] SHARMA M K,SHARMA A,KUMAR A,et al.Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice[J].Food & Chemical Toxicology,2007,45(12):2 412-2 419.
[37] KEPEKI R A,POLAT S,ELIK A,et al.Protective effect of Spirulina platensis enriched in phenolic compounds against hepatotoxicity induced by CCl4[J].Food Chemistry,2013,141(3):1 972-1 979.
[38] 王慧,姚三巧,白玉萍,等.螺旋藻干粉对电离辐射所致小鼠血像改变的影响[J].中国职业医学,2003,30(1):45-47.WANG H,YAO S Q,BAI Y P,et al.Effect of Spirulina platensis dry powder on blood picture of rats irradiated by X-ray acutely[J].China Occup Med,2003,30(1):45-47.
[39] 崔文明,张馨,刘泽钦,等.螺旋藻抗辐射作用研究[J].毒理学杂志,2002,16(3):174-175.CUI W M,ZHANG X,LIU Z Q,et al.Study on the anti-radiation effect of Spirulina[J].Health Toxicol,2002,16(3):174-175.
[40] 吴显劲,黄斌,孟庆勇.钝顶螺旋藻多糖对辐射损伤小鼠细胞增殖的影响[J].山东医药,2005(35):8-9.WU X J,HUANG B,MENG Q Y.Effects of Spirulina blunthorn polysaccharide on cell proliferation in radiation-injured mice[J].Shandong Medicine,2005(35):8-9.
[41] 左绍远,钱金栿,万顺康,等.钝顶螺旋藻多糖降血糖调血脂实验研究[J].中国生化药物杂志,2000(6):289-291.ZUO S Y,QIAN J F,WAN S K,et al.Research of Polysaccharide from Spirulina platensis on hypoglycemic and hypolipidemic effect in experimental diabetic rats[J].Chinese Journal of Biochemical Pharmaceutics,2000(6):289-291.
[42] 陈雨豪,王峰,周嘉威,等.螺旋藻肽对四氧嘧啶诱导的糖尿病小鼠作用研究[J].宁波大学学报(理工版),2020,33(3):13-18.CHEN Y H,WANG F,ZHOU J W,et al.The effects of Spirulina peptides on alloxan-induced diabetic mice[J].Journal of Ningbo University(Ness),2020,33(3):13-18.
[43] HENRIKSON R.Earth food Spirulina[M].6th ed.Hawaii:Ronore Enterprises Inc,2009:18.
[44] CIFERRI O.螺旋藻:食用微生物[J].林励,译.海南大学学报(自然科学版)自然科学版,1989(2):101-107.CIFERRI O.Spirulina:Edible microorganisms[J].LIN L.Journal of Hainan University(Natural Science),1989(2):101-107.
[45] MARLES R J,BARRETTM L,BARNES J,et al.United Statespharma copeia safety evaluation of Spirulina[J].Critical Reviews in Food Science and Nutrition,2011,51(7):593-600.
[46] 萨翼,李淑娟,陈晓怡.我国保健食品的市场准入制度及对未来产品研发的启示和展望[J].食品安全质量检测学报,2021,12(11):4 446-4 452.SA Y,LI S J,CHEN X Y.Enlightenment and prospect of market access system of China's dietary supplement for future product research and development[J].Journal of Food Safety and Quality,2021,12(11):4 446-4 452.
[47] 李昇刚,方选,丛江.螺旋藻片对小鼠骨髓细胞染色体致畸变实验[J].中国药师,2009,12(1):74-75.LI S G,FANG X,CONG J.Experimental of Spirulina on chromosome aberration in bone marrow cells of mice[J].China Pharmaceutical Affairs,2009,12(1):74-75.
[48] 方选,李昇刚.螺旋藻片对小鼠睾丸染色体致畸变实验研究[J].中国药事,2009,23(12):1 187-1 188.FANG X,LI S G.Studies on the impact of Spirulina on chromosome aberration in testicle cells of mice[J].China Pharmaceutical Affairs,2009,23(12):1 187-1 188.
[49] 黄天宏,张熠,张盈,等.螺旋藻多糖对小鼠精子和睾丸细胞染色体畸变研究[J].海峡药学,2017,29(11):15-17.HUANG T H,ZHANG Y,ZHANG Y,et al.Study on the Spirulina polysaccharides on sperm abnormality and chromosome aberration in testicle cell of mice[J].Strait Pharmacy,2017,29(11):15-17.
[50] 陈妍,蒋萌.螺旋藻多糖胶囊人体耐受性试验[J].中国医学创新,2009,6(13):17-19.CHEN Y,JIANG M.Human tolerance test of Spirulina polysaccharide capsule[J].Medical Innovation in China,2009,6(13):17-19.
[51] 国家市场监督管理总局.市场监管总局关于公开征求辅酶Q10等5种保健食品原料目录意见的公告[EB/OL].(2019-03-28)[2022-06-08].https://www.samr.gov.cn/tssps/sjdt/gzdt/201904/t20190402_292515.html.State Administration for Market Regulation.Announcement on publicly soliciting opinions on the dosage form and quality of five raw materials for health food such as coenzyme Q10[EB/OL].(2019-03-28)[2022-06-08].https://www.samr.gov.cn/tssps/sjdt/gzdt/201904/t20190402_292515.html.
[52] 任顺成,曹悦,李林政,等.天然食用色素藻蓝蛋白研究进展[J].食品研究与开发,2021,42(7):203-208.REN S C,CAO Y,LI L Z,et al.Research progress of natural food pigmentphycocyanin[J].Food Research and Development,2021,42(7):203-208.
[53] 冯亚非,温燕梅,李先文.藻蓝:富有营养保健功能的天然色素[J].食品科技,2007,32(6):171-173.FENG Y F,WEN Y M,LI X W.Spirulina blue-natural pigment with nutrition and health function[J].Food Science and Tehnology,2007,32(6):171-173.
[54] 姜国庆,闫秋丽,李东,等.螺旋藻中藻蓝蛋白提取、纯化及稳态化研究进展[J].食品安全质量检测学报,2021,12(6):2 332-2 338.JIANG G Q,YAN Q L,LI D,et al.Research progress on separation,purification and stabilization of phycocyanin from Spirulina[J].Journal of Food Safety and Quality,2021,12(6):2 332-2 338.
[55] 俞建峰,傅剑,马潇,等.细胞破壁对螺旋藻藻蓝蛋白提取效果的影响[J].食品与机械,2017,33(5):173-177.YU J F,FU J,MA X,et al.Comparison of cell disruption methods for the extraction of Phycocyanin from Spirulina Platensis[J].Food & Machinery,2017,33(5):173-177.
[56] KANNAUJIYA V K,SINHA R P.Thermokinetic stability of phycocyaninand phycoerythrin in food-grade preservatives[J].Journal of Applied Phycology,2016,28(2):1 063-1 070.
[57] KISSOUDI M,SARAKATSIANOS I,SAMANIDOU V.Isolationandpurification of food-grade C-phycocyanin from Arthrospira platensis andits determination in confectionery by HPLC with diode array detection[J].J Sep Sci,2018,41(4):975-981.
[58] 国家卫生和计划生育委员会.食品安全国家标准保健食品:GB 16740—2014[S].北京:中国标准出版社,2014:1.State Health and Family Planning Commission of the People' s Republic of China.National food safety standards health food:GB 16740—2014[S].Beijing:China Standards Press,2014:1.
[59] 魏玉翠,谢定,刘永乐,等.螺旋藻脱腥工艺优化及其强化米粉的研制[J].食品与机械,2011,27(1):136-139.WEI Y C,XIE D,LIU Y L,et al.Study on removing off flavor ofspirulina and manufacturing rice noodle with deodorized spirulina[J].Food & Machinery,2011,27(1):136-139.
[60] 王惜纯.螺旋藻产业发展迎来黄金期[N].中国质量报,2020-11-24(7).WANG X C.The development of Spirulina industry ushered in a golden period[N].China Quality News,2020-11-24(7).
[61] 陆悦.由单一原料向多元化应用转型—螺旋藻产业迎来“第四次浪潮”[N].中国医药报,2018-09-13(7).LU Y.The Spirulina industry ushered in the "fourth wave"[N].China Medical News,2018-09-13(7).
[62] 国家市场监督管理总局.关于公开征求《关于发布允许保健食品声称的保健功能目录非营养素补充剂(2022年版)及配套文件的公告(征求意见稿)》意见的反馈[EB/OL].(2022-04-07)[2022-06-08].https://www.samr.gov.cn/hd/zjjg/202204/t20220407_341142.html.State Administration for Market Regulation.Feedback on public solicitation of 《Health Care Function List of Health food Non-nutrient supplement(2022)》and supportive documents(Draft for comments)[EB/OL].(2022-04-07)[2022-06-08].https://www.samr.gov.cn/hd/zjjg/202204/t20220407_341142.html.