Abstract
To use the solid dispersion method that could improve the dissolution rate of chlorogenic acid.With the factor experiment design, chlorogenic acid solid was mixed with PVPK30 and PEG4000 respectively, with the feed auxiliary ratio of 12, 14, 16, 18. The finished product of solid dispersion prepared by four types of mixture ratio were compared in the vitro solubility, cumulative dissolution and stability, and the optimal mixture ratio was analyzed by SEM. The experiment showed that chlorogenic acid solid dispersion could be prepared by mixture ratio of 14, with PVPK30 as carrier. Compared with crude drugs, in vitro solubility and dissolution of chlorogenic acid solid dispersion increased obviously. With the SEM, chlorogenic acid existed in PVPK30 as the form of non-crystal, the surface with many small holes that could improve the dissolution and absorption. Chlorogenic acid-PVPK30 solid dispersion improves the properties of solubility and dissolution, better than those of raw medicine.
Publication Date
12-28-2017
First Page
45
Last Page
49
DOI
10.13652/j.issn.1003-5788.2017.12.009
Recommended Citation
Yan, LI; Jie, WANG; Keke, CAO; Zhanggui, WANG; and Di, WANG
(2017)
"Analysis and comparison on solid ispersion performance of dandelion chlorogenic acid,"
Food and Machinery: Vol. 33:
Iss.
12, Article 9.
DOI: 10.13652/j.issn.1003-5788.2017.12.009
Available at:
https://www.ifoodmm.cn/journal/vol33/iss12/9
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