Research progress on the mechanism of dietary polyphenols in improving inflammatory bowel disease

Authors

LIN Peng-cheng, College of Mairine Science and Biological Engineering, Qingdao University of Science & Technology, Qingdao, Shandong 266042, China
CAO Jun-han, College of Mairine Science and Biological Engineering, Qingdao University of Science & Technology, Qingdao, Shandong 266042, China
XIE Wan-cui, College of Mairine Science and Biological Engineering, Qingdao University of Science & Technology, Qingdao, Shandong 266042, China; Key Laboratory for Biochemical Engineering of Shandong Province, Qingdao, Shandong 266042, China; Shandong Searsport Bio-tech Co., Ltd., Linyi, Shandong 276000, China; Shanghao Science and Technology Co., Ltd., Qingdao, Shandong 266002, China

Abstract

This article summarizes the mechanism by which dietary polyphenols improve inflammatory bowel disease by regulating oxidative stress, protecting the intestinal mucosal barrier, regulating intestinal flora and metabolites, highlights the regulatory effect of dietary polyphenols on inflammatory bowel disease inflammatory signaling pathways, and prospects to the research direction of dietary polyphenols in the nutritional intervention field of inflammatory bowel disease and other diseases.

Publication Date

9-28-2021

First Page

205

Last Page

210

DOI

10.13652/j.issn.1003-5788.2021.09.033

Recommended Citation

Peng-cheng, LIN; Jun-han, CAO; and Wan-cui, XIE (2021) "Research progress on the mechanism of dietary polyphenols in improving inflammatory bowel disease," Food and Machinery: Vol. 37: Iss. 9, Article 33.
DOI: 10.13652/j.issn.1003-5788.2021.09.033
Available at: https://www.ifoodmm.cn/journal/vol37/iss9/33

References

[1] UEDA Y, KAWAKAMI Y, KUNII D, et al. Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease[J]. Nutrition Research, 2008, 28（4）: 239-244.
[2] POLINSKA B, MATOWICKA-KARNA J, KEMONA H. The cytokines in inflammatory bowel disease[J]. Postepy Higieny I Medycyny Doswiadczalnej, 2009, 63: 389-394.
[3] CARDONA F, ANDRES-LACUEVA C, TULIPANI S, et al. Benefits of polyphenols on gut microbiota and implications in human health[J]. Journal of Nutritional Biochemistry, 2013, 24（8）: 1 415-1 422.
[4] GUO Wei-min, KONG E, MEYDANI M. Dietary polyphenols, inflammation, and cancer[J]. Nutrition and Cancer-an International Journal, 2009, 61（6）: 807-810.
[5] FARZAEI M H, RAHIMI R, ABDOLLAHI M. The role of dietary polyphenols in the management of inflammatory bowel disease[J]. Current Pharmaceutical Biotechnology, 2015, 16（3）: 196-210.
[6] PIECHOTA-POLANCZYK A, FICHNA J. Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases[J]. Naunyn-Schmiedebergs Archives of Pharmacology, 2014, 387（7）: 605-620.
[7] ACHITEI D, CIOBICA A, BALAN G, et al. Different profile of peripheral antioxidant enzymes and lipid peroxidation in active and non-active inflammatory bowel disease patients[J]. Digestive Diseases and Sciences, 2013, 58（5）: 1 244-1 249.
[8] OZ H S, CHEN T S, MCCLAIN C J, et al. Antioxidants as novel therapy in a murine model of colitis[J]. Journal of Nutritional Biochemistry, 2005, 16（5）: 297-304.
[9] BRUECKNER M, WESTPHAL S, DOMSCHKE W, et al. Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis[J]. Journal of Crohns & Colitis, 2012, 6（2）: 226-235.
[10] OGAWA Y, KANATSU K, IINO T, et al. Protection against dextran sulfate sodium-induced colitis by microspheres of ellagic acid in rats[J]. Life Sciences, 2002, 71（7）: 827-839.
[11] SANCHEZ DE MEDINA F, VERA B, GALVEZ J, et al. Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat[J]. Life Sciences, 2002, 70（26）: 3 097-3 108.
[12] SEIBEL J, MOLZBERGER A F, HERTRAMPF T, et al. Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis[J]. European Journal of Nutrition, 2009, 48（4）: 213-220.
[13] KWON H S, OH S M, KIM J K. Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis[J]. Clinical and Experimental Immunology, 2008, 151（1）: 165-173.
[14] AL-REJAIE S S, ABUOHASHISH H M, AL-ENAZI M M, et al. Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats[J]. World Journal of Gastroenterology, 2013, 19（34）: 5 633-5 644.
[15] REN Gai-yan, SUN A-ning, DENG Chao, et al. The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis[J]. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2015, 309（7）: G517-G527.
[16] RAHMAN S U, LI Yu, HUANG Ying-ying, et al. Treatment of inflammatory bowel disease via green tea polyphenols: Possible application and protective approaches[J]. Inflammopharmacology, 2018, 26（2）: 319-330.
[17] ROMIER B, VAN DE WALLE J, DURING A, et al. Modulation of signalling nuclear factor-kappa B activation pathway by polyphenols in human intestinal Caco-2 cells[J]. British Journal of Nutrition, 2008, 100（3）: 542-551.
[18] NUNES C, FERREIRA E, FREITAS V, et al. Intestinal anti-inflammatory activity of red wine extract: Unveiling the mechanisms in colonic epithelial cells[J]. Food & Function, 2013, 4（3）: 373-383.
[19] DOU Wei, ZHANG Jing-jing, SUN A-ning, et al. Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling[J]. British Journal of Nutrition, 2013, 110（4）: 599-608.
[20] ANTONIA C, ROSA C, PASQUA C, et al. Modulation of NF-κB activation by resveratrol in LPS treated human intestinal cells results in downregulation of PGE 2 production and COX-2 expression[J]. Toxicology in Vitro, 2012, 26（7）: 1 122-1 128.
[21] ZHANG Xing-xing, WU Jian, YE Bo, et al. Protective effect of curcumin on TNBS-induced intestinal inflammation is mediated through the JAK/STAT pathway[J]. Bmc Complementary and Alternative Medicine, 2016, 16（1）: 299.
[22] NUNES C, ALMEIDA L, BARBOSA R M, et al. Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation[J]. Food & Function, 2017, 8（1）: 387-396.
[23] SERRA D, RUFINO A T, MENDES A F, et al. Resveratrol modulates cytokine-induced JAK/STAT activation more efficiently than 5-aminosalicylic acid: An in vitro approach[J]. PLoS One, 2014, 9（10）: e109048.
[24] ANDLUJAR I, CARMEN RECIO M, GINER R M, et al. Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells[J]. Journal of Agricultural and Food Chemistry, 2011, 59（12）: 6 474-6 483.
[25] SAADATDOUST Z, PANDURANGAN A K, SADAGOPAN S K A, et al. Dietary cocoa inhibits colitis associated cancer: A crucial involvement of the IL-6/STAT3 pathway[J]. Journal of Nutritional Biochemistry, 2015, 26（12）: 1 547-1 558.
[26] ZHENG Rong-juan, MA Jia-heng, WANG Dan, et al. Chemopreventive effects of silibinin on colitis-associated tumorigenesis by inhibiting IL-6/STAT3 signaling pathway[J]. Mediators of Inflammation, 2018, 2 018: 1-15.
[27] HUO Xiao-wei, LIU Dong-yu, GAO Li, et al. Flavonoids extracted from licorice prevents colitis-associated carcinogenesis in AOM/DSS mouse model[J]. International Journal of Molecular Sciences, 2016, 17（9）: 1 343.
[28] SANCHEZ-FIDALGO S, CARDENO A, SANCHEZ-HIDALGO M, et al. Dietary extra virgin olive oil polyphenols supplementation modulates DSS-induced chronic colitis in mice[J]. Journal of Nutritional Biochemistry, 2013, 24（7）: 1 401-1 413.
[29] DOU Wei, ZHANG Jing-jing, REN Gai-yan, et al. Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-kappa B and MAPK signaling inactivation[J]. International Immunopharmacology, 2014, 23（1）: 170-178.
[30] HUANG Yi-na, XING Ke-yu, QIU Liang, et al. Therapeutic implications of functional tea ingredients for ameliorating inflammatory bowel disease: A focused review[J]. Critical Reviews in Food Science and Nutrition, 2021（4）: 1-15.
[31] 丛馨, 张艳, 俞光岩, 等. 上皮细胞间紧密连接功能的研究进展[J]. 生理学报, 2016, 68（4）: 492-504.
[32] ERLEJMAN A G, FRAGA C G, OTEIZA P I. Procyanidins protect Caco-2 cells from bile acid- and oxidant-induced damage[J]. Free Radical Biology & Medicine, 2006, 41（8）: 1 247-1 256.
[33] NAKAHARA T, NISHITANI Y, NISHIUMI S, et al. Astilbin from Engelhardtia chrysolepis enhances intestinal barrier functions in Caco-2 cell monolayers[J]. European Journal of Pharmacology, 2017, 804: 46-51.
[34] SHIGESHIRO M, TANABE S, SUZUKI T. Dietary polyphenols modulate intestinal barrier defects and inflammation in a murine model of colitis[J]. Journal of Functional Foods, 2013, 5（2）: 949-955.
[35] MARTIN A R, VILLEGAS I, LA CASA C, et al. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats[J]. Biochemical Pharmacology, 2004, 67（7）: 1 399-1 410.
[36] ROSILLO M A, SANCHEZ-HIDALGO M, CARDENO A, et al. Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease[J]. Biochemical Pharmacology, 2011, 82（7）: 737-745.
[37] GEORGIADES P, PUDNEY P D A, ROGERS S, et al. Tea derived galloylated polyphenols cross-link purified gastrointestinal mucins[J]. PLoS One, 2014, 9（8）: e105302.
[38] GONZALEZ-MARISCAL L, TAPIA R, CHAMORRO D. Crosstalk of tight junction components with signaling pathways[J]. Biochimica Et Biophysica Acta-Biomembranes, 2008, 1 778（3）: 729-756.
[39] PARK J H, PEYRIN-BIROULET L, EISENHUT M, et al. Inflammatory bowel diseases （IBD） immunopathogenesis: A comprehensive review of inflammatory molecules[J]. Autoimmunity Reviews, 2017, 16（4）: 416-426.
[40] CHEN Tao, HU Shi-hui, ZHANG Hai-wen, et al. Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model[J]. Food & Function, 2017, 8（2）: 659-669.
[41] 席进, 葛思堂, 左芦根, 等. 绿茶多酚抑制肠道JAK2/STAT3信号通路保护三硝基苯磺酸诱导的小鼠结肠炎肠黏膜屏障[J]. 细胞与分子免疫学杂志, 2018, 34（3）: 237-241.
[42] 吴维, 孙明明, 刘占举. 饮食因素对炎症性肠病的影响[J]. 中华炎性肠病杂志, 2019（1）: 49-51.
[43] 钟海平, 郑红斌. 丁酸在溃疡性结肠炎中的作用概述[J]. 中医临床研究, 2011, 3（9）: 113-115.
[44] 岳莹雪, 王玉琦, 闫芬芬, 等. 丁酸的生产方法及在肠道中的生理功能研究进展[J]. 食品工业科技, 2019, 40（15）: 339-344.
[45] BHAT M I, KAPILA R. Dietary metabolites derived from gut microbiota: Critical modulators of epigenetic changes in mammals[J]. Nutrition Reviews, 2017, 75（5）: 374-389.
[46] NEYRINCK A M, VAN HEE V F, BINDELS L B, et al. Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota[J]. British Journal of Nutrition, 2013, 109（5）: 802-809.
[47] LARROSA M, LUCERI C, VIVOLI E, et al. Polyphenol metabolites from colonic microbiota exert anti-inflammatory activity on different inflammation models[J]. Molecular Nutrition & Food Research, 2009, 53（8）: 1 044-1 054.
[48] DOLARA P, LUCERI C, DE FILIPPO C, et al. Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats[J]. Mutation Research, 2005, 591（1/2）: 237-246.
[49] 魏俊淑. 植物乳杆菌调节小鼠肠道菌群预防DSS诱导结肠炎的研究[D]. 兰州: 兰州大学, 2018: 54.
[50] GILL P A, VAN ZELM M C, MUIR J G, et al. short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders[J]. Alimentary Pharmacology & Therapeutics, 2018, 48（1）: 15-34.
[51] LI Rui-qi, WANG Gary P, WHITLOCK J A, et al. Muscadine grapes （Vitis rotundifolia） and dealcoholized muscadine wine alleviated symptoms of colitis and protected against dysbiosis in mice exposed to dextran sulfate sodium[J]. Journal of Functional Foods, 2020, 65: 103746.