Abstract
Angiotensin -converting enzyme (ACE ) inhibitory peptides act as natural and safe agents for hypertension intervention by specifically binding to the ACE active center and thereby blocking the pressor pathway of the renin -angiotensin system (RAS ). In response to the bottlenecks of low efficiency and high cost associated with conventional screening approaches, this paper systematically reviews structure -oriented screening technologies for food -derived ACE inhibitory peptides. Key methodologies are discussed in terms of their principles and applications, including database -based targeted screening, molecular simulation of enzymatic hydrolysis, structure -activity relationship modeling, molecular docking, and kinetic simulation. Furthermore, recent research advances on ACE inhibitory peptides from different sources are summarized, with a focus on four major categories:marine organisms, plants, animal -derived materials, and fermented dairy products.
Publication Date
11-3-2026
First Page
205
Last Page
213
DOI
10.13652/j.spjx.1003.5788.2025.60164
Recommended Citation
Chenliang, Yu; Jinlin, Yang; Fangfang, Wang; and Qingguo, Yan
(2026)
"A review of sources and screening methods for food-derived ACE inhibitory peptides,"
Food and Machinery: Vol. 42:
Iss.
10, Article 24.
DOI: 10.13652/j.spjx.1003.5788.2025.60164
Available at:
https://www.ifoodmm.cn/journal/vol42/iss10/24
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