•  
  •  
 

Corresponding Author(s)

张柏林(1963—),男,北京林业大学教授,博士。E-mail:zhangbolin888@163.com

Abstract

Mineral element deficiency can cause many health problems. Traditional metal element supplements have many shortcomings. Food-derived metal element supplements have gradually become a research hotspot. Plant-derived polypeptides have significant advantages in terms of cost and raw material sources. Chelating peptides formed by chelating metal ions with plant-derived polypeptides have the physiological activity of peptides and the functional characteristics of metal elements, which makes them relatively ideal nutritional supplements, showing broad development prospects. This paper collects relevant research reports at home and abroad, and sorts out the preparation process, chelation mechanism and characteristics, and biological activity of plant-derived metal ion chelating peptides. The paper provides an outlook on the development trend and large-scale application prospect of plant-derived metal ion chelating peptides in basic research, application scenarios, and industrial transformation.

Publication Date

7-25-2026

First Page

203

Last Page

209

DOI

10.13652/j.spjx.1003.5788.2025.80280

References

[1] Suzuki Y,Landowski C P,Hediger M A.Mechanisms and regulation of epithelial Ca2+ absorption in health and disease [J].Annual Review of Physiology,2008,70:257-271.

[2] Singh P,Prasad S.A review on iron,zinc and calcium biological significance and factors affecting their absorption and bioavailability [J].Journal of Food Composition and Analysis,2023,123:105529.

[3] Guo L D,Harnedy P A,Li B F,et al.Food protein-derived chelating peptides:biofunctional ingredients for dietary mineral bioavailability enhancement [J].Trends in Food Science & Technology,2014,37(2):92-105.

[4] 刘凌云.国内外多肽金属离子螯合物的研究进展 [J].化工设计通讯,2023,49(8):32-34.Liu L Y.Research progress in peptide metal ion chelates at home and abroad [J].Chemical Engineering Design Communications,2023,49(8):32-34.

[5] Langyan S,Yadava P,Khan F N,et al.Sustaining protein nutrition through plant-based foods [J].Frontiers in Nutrition,2022,8:772573.

[6] Da Silva Crozatti T T,Miyoshi J H,Tonin A P P,et al.Obtaining of bioactive di-and tripeptides from enzymatic hydrolysis of soybean meal and its protein isolate using Alcalase® and Neutrase® [J].International Journal of Food Science & Technology,2023,58(3):1 586-1 596.

[7] Du K,Tian S Q,Chen H,et al.Application of enzymes in the preparation of wheat germ polypeptides and their biological activities [J].Frontiers in Nutrition,2022,9:943950.

[8] 李云亮,王晓静,阮思煜,等.玉米多肽制备方法及其功能活性研究进展 [J].食品工业科技,2022,43(2):434-441.Li Y L,Wang X J,Ruan S Y,et al.Research progress on preparation and functional activity of corn polypeptides [J].Science and Technology of Food Industry,2022,43(2):434-441.

[9] 乔虹,黎松松,周南希,等.海洋来源金属离子螯合肽研究进展[J].食品工业科技,2024,45(1):368-377.Qiao H,Li S S,Zhou N X,et al.Research progress in metal ion chelated peptides of marine sources [J].Science and Technology of Food Industry,2024,45(1):368-377.

[10] 陈卓,秦丹,李先奇.植物蛋白源抗氧化肽的研究进展 [J].中国食物与营养,2012,18(4):37-39.Chen Z,Qin D,Li X Q.Research on antioxidant peptide from plant protein [J].Food and Nutrition in China,2012,18(4):37-39.

[11] Meinlschmidt P,Schweiggert-Weisz U,Eisner P.Soy protein hydrolysates fermentation:effect of debittering and degradation of major soy allergens [J].LWT-Food Science & Technology,2016,71:202-212.

[12] 阮晓慧,韩军岐,张润光,等.食源性生物活性肽制备工艺、功能特性及应用研究进展 [J].食品与发酵工业,2016,42(6):248-253.Ruan X H,Han J Q,Zhang R G,et al.Progress in the preparation,functional properties and applications of food-derived bioactive peptides [J].Food and Fermentation Industry,2016,42(6):248-253.

[13] 周莹,石景,邹烨,等.食源性肽铁螯合物研究进展 [J].食品工业科技,2024,45(14):418-425.Zhou Y,Shi J,Zou Y,et al.Research progress on iron chelates of foodborne peptides [J].Science and Technology of Food Industry,2024,45(14):418-425.

[14] Zhai W L,Lin D,Mo R S,et al.Process optimization,structural characterization,and calcium release rate evaluation of mung bean peptides-calcium chelate [J].Foods,2023,12(5):1 058.

[15] 刘畅,肖涵波,李方杰,等.高压脉冲电场技术制备大豆肽螯合钙 [J].食品安全质量检测学报,2015 (6):2 138-2 144.Liu C,Xiao H B,Li F J,et al.Preparation of soybean protein hydrolysates chelating calcium with pulses electric field technology [J].Journal of Food Safety & Quality,2015 (6):2 138-2 144.

[16] 李安平,杨玉蓉,钟政昌,等.一种固体脂质桃仁多肽亚铁螯合物纳米颗粒及其制备方法:CN201710844170.1[P].2020-05-08.Li A P,Yang Y R,Zhong Z C,et al.A solid lipid peach kernel polypeptide ferrous chelate nanoparticle and its preparation method:CN201710844170.1[P].2020-05-08.

[17] 李玉珍,肖怀秋,姜明姣,等.响应面优化微波固相合成花生肽亚铁金属配位整合工艺 [J].中国油脂,2017,42(9):38-43.Li Y Z,Xiao H Q,Jiang M J.Optimization of microwave solid-phase synthesis of peanut peptide-ferrous metal coordination chelating technology by response surface methodology [J].China Oils and Fats,2017,42(9):38-43.

[18] Lin S T,Hu X,Yang X Q,et al.GLPGPSGEEGKR:Fe2+ chelating characterization and potential transport pathways for improving Fe2+ bioavailability in Caco-2 cells [J].Food Bioscience,2022,48:101806.

[19] Liu W Y,Wu H S,Liu R,et al.Structural identification,stability and combination mechanism of calcium-chelating wheat gluten peptides [J].International Journal of Food Engineering,2024,20(5):303-313.

[20] Liu F R,Wang L,Wang R.Calcium-binding capacity of wheat germ protein hydrolysate and characterization of peptide-calcium complex [J].Journal of Agricultural and Food Chemistry,2013,61(31):7 537-7 544.

[21] Eckert E,Bamdad F,Chen L.Metal solubility enhancing peptides derived from barley protein [J].Food Chemistry,2014,159:498-506.

[22] Lv Y,Bao X L,Yang B C,et al.Effect of soluble soybean protein hydrolysate-calcium complexes on calcium uptake by caco-2 cells [J].Journal of Food Science,2008,73(7):H168-H173.

[23] Torres-Fuentes C,Alaiz M,Vioque J.Iron-chelating activity of chickpea protein hydrolysate peptides [J].Food Chemistry,2012,134(3):1 585-1 588.

[24] Zhao S B,Wang L,Liang J Y,et al.Preparation,characterization and microencapsulation of walnut (Juglans regia L.) peptides-zinc chelate [J].Journal of Food Science,2024,89(9):5 618-5 632.

[25] An J L,Wang Y M,Li W H,et al.Evaluating the capability of soybean peptides as calcium ion carriers:a study through sequence analysis and molecular dynamics simulations [J].RSC Advances,2024,14(22):15 542-15 553.

[26] Bao X L,Yuan X Y,Feng G X,et al.Structural characterization of calcium-binding sunflower seed and peanut peptides and enhanced calcium transport by calcium complexes in Caco-2 cells [J].Journal of the Science of Food and Agriculture,2021,101(2):794-804.

[27] Bu G H,Zhao X L,Wang M L,et al.Identification of calcium chelating peptides from peanut protein hydrolysate and absorption activity of peptide-calcium complex [J].Journal of the Science of Food and Agriculture,2024,104(11):6 676-6 686.

[28] 门德盈,王增丽,项全燕,等.超声波、微波预处理对核桃粕蛋白肽钙螯合能力、结构及稳定性的影响 [J].食品科学,2024,45(8):193-201.Men D Y,Wang Z L,Xiang Q Y,et al.Effects of ultrasonic and microwave pretreatments on calcium chelating capacity,structure and stability of walnut meal protein peptides [J].Food Science,2024,45(8):193-201.

[29] Zhang Y J,Ding X J,Li M Q.Preparation,characterization and in vitro stability of iron-chelating peptides from mung beans [J].Food Chemistry,2021,349(1):129101.

[30] 冷雨佳.大豆肽锌螯合物的制备、螯合机理及其生物活性研究[D].郑州:河南工业大学,2022:43-47.Leng Y J.Study on preparation,chelation mechanism and biological activity of soybean peptide zinc chelates [D].Zhengzhou:Henan University of Technology,2022:43-47.

[31] Wang L,Ding Y,Zhang X,et al.Isolation of a novel calcium-binding peptide from wheat germ protein hydrolysates and the prediction for its mechanism of combination [J].Food Chemistry,2018,239:416-426.

[32] Bu G H,Zhai G H,Zhao X L,et al.Isolation,identification,and chelation mechanism of ferrous-chelating peptide from peanut protein hydrolysate [J].Journal of the Science of Food and Agriculture,2024,104(15):9 368-9 378.

[33] 邓叶俊,黄立新,张彩虹,等.木瓜籽肽—锌螯合物的制备、结构表征及稳定性研究 [J].林产化学与工业,2023,43(5):73-80.Deng Y J,Huang L X,Zhang C H,et al.Preparation,structural characterization and stability of Chinese quince seed peptide-zinc chelate [J].Chemistry and Industry of Forest Products,2023,43(5):73-80.

[34] Zhang L L,Pan D,Shao L H,et al.Oil palm kernel globulin antihypertensive peptides:isolation and characterization,ACE inhibition mechanisms,zinc-chelating activity,security and stability [J].Frontiers in Pharmacology,2023,14:1225256.

[35] 赵梓月,王思远,廖森泰,等.多肽螯合钙的研究进展 [J].食品研究与开发,2020,41(5):200-206.Zhao Z Y,Wang S Y,Liao S T,et al.Progress in research on peptide chelated calcium [J].Food Research and Development,2020,41(5):200-206.

[36] 刘凤茹.麦胚蛋白聚集行为及其钙离子螯合肽的制备与评价[D].无锡:江南大学,2014:53-58.Liu F R.The aggregation behavior of wheat germ protein and the preparation and evaluation of calcium chelating peptides[D].Wuxi:Jiangnan University,2014:53-58.

[37] 秦修远,刘文颖,张静波,等.豌豆低聚肽硒螯合物的稳定性研究 [J].食品与发酵工业,2019,45(2):74-79.Qin X Y,Liu W Y,Zhang J B,et al.Stability of selenium-chelating pea oligopeptide [J].Food and Fermentation Industries,2019,45(2):74-79.

[38] 刘春燕.西瓜籽肽与钙螯合物的制备及其功能特性研究 [D].镇江:江苏大学,2022:52-58.Liu C Y.Preparation and functional properties of watermelon seed peptide and calcium chelate [D].Zhenjiang:Jiangsu University,2022:52-58.

[39] Fan C Z,Wang X T,Song X W,et al.Identification of a novel walnut iron chelating peptide with potential high antioxidant activity and analysis of its possible binding sites [J].Foods,2023,12(1):226.

[40] 郑义,李诗颖,李闯,等.银杏肽锌螯合物的制备、体外消化及抗氧化活性分析 [J].食品工业科技,2023,44(17):420-427.Zheng Y,Li S Y,Li C,et al.Preparation,in vitro gastrointestinal digestion and antioxidant activity of ginkgo biloba peptides-zinc chelate [J].Science and Technology of Food Industry,2023,44(17):420-427.

[41] Qu W J,Li Y H,Xiong T,et al.Calcium-chelating improved zein peptide stability,cellular uptake,and bioactivity by influencing the structural characterization [J].Food Research International,2022,162(Pt A):112033.

[42] 杨玉蓉,李安平,钟政昌,等.桃仁多肽螯合亚铁的抑菌活性及结构表征 [J].食品科学,2019,40(5):57-62.Yang Y R,Li A P,Zhong Z C,et al.Antibacterial activity and structural characterization of peach kernel peptide-ferrous chelate [J].Food Science,2019,40(5):57-62.

[43] 蒲传奋,唐文婷.玉米醇溶蛋白肽钙螯合物的制备及其抑菌性能研究 [J].食品科技,2015,40(12):246-250.Pu C F,Tang W T.Preparation and antibacterial properties of zein peptide-calcium chelate [J].Food Science and Technology,2015,40(12):246-250.

[44] Zhang Z,Sun J J,Li Y X,et al.Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease [J].Experimental Gerontology,2023,183:112308.

[45] Zhao F R,Hou W Y,Guo L X,et al.Novel strategy to the characterization and enhance the glycemic control properties of walnut-derived peptides via zinc chelation [J].Food Chemistry,2024,441:138288.

[46] 张兆中.核桃多肽—亚铁螯合物的制备及其功能性饮料的开发 [D].石家庄:河北科技大学,2023:59-63.Zhang Z Z.Preparation of polypeptide-ferrous chelate from walnut and development of functional beverage [D].Shijiazhuang:Hebei University of Science and Technology,2023:59-63.

[47] 江轶群.功能性大豆肽基纳米颗粒的钙离子螯合及微囊化研究 [D].广州:华南理工大学,2022:62-66.Jiang Y Q.Calcium chelation and microencapsulation of functional soybean peptide-based particles [D].Guangzhou:South China University of Technology,2022:62-66.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.