The N-aryl Chitooligosaccharides (COS) derivatives were firstly synthesized with Benzaldehyde, salicylal and 3,4-two hydroxy benzaldehyde, subsequently was quaternized to enhance its water solubility.The chemical structures of all COS derivatives were characterized by ATR-FTIR or 1H NMR. The antibacterial studies of these COS derivatives were carried out by the inhibition zone diameters methods against E.coli, S.aurueus and P.aeruginosa bacteria. The antibacterial activity results showed N-3,4-two hydroxy benzaldehyde Schiff’s base COS > N-salicylal Schiff’s base COS > N- Benzaldehyde Schiff’s base COS> COS. In comparison to the COS derivatives chemical structure, it was found that the phenol hydroxyl group from N-aryl Schiff COS could improved the antibacterial activity, and the samller of its steric hindrance the more high of the antibacterial activity.
Yongping, HAN; Ping, GONG; and Keyi, LI
"Study on antibacterial activity of phenol hydroxyl from N-aryl Schiff COS derivatives,"
Food and Machinery: Vol. 31:
1, Article 30.
Available at: https://www.ifoodmm.cn/journal/vol31/iss1/30
 刘振儒,赵江霞.水溶性壳聚糖季铵盐的抗菌性能［J］.青岛科技大学学报,2007, 27(4):317～319.
 赵希荣,夏文水.二元取代壳聚糖季铵盐的抗菌活性［J］.食品与微生物技术学报,2006, 25(5): 55～60.
 裴立军,蔡照胜,商士斌,等.碱性离子液体条件下烷基化壳聚糖衍生物的制备及其抑菌性能研究［J］.林产化学与工业, 2014, 34(3):44～50.
 李小芳,冯小强,杨声,等. O-羧甲基化壳聚糖季铵盐的制备及抑菌活性［J］.食品科学,2011, 32(9):79～81.
 Kim Y H, Choi H M, Yoon J H. Synthesis of a quaternary ammonium derivative of chitosan and its application actton antimicrobial finish［J］.Text. Res. J., 1998, 68(6): 428～434.