Magnetic nanoparticles is a kind of new polymer materials, which has been widely used in the field of biomedical, food and environment in recent years.The magnetic nanoparticles with suitable surface modification are capable of binding molecules selectively and has property of special magnetic response. In this review, the research progress on applications of magnetic nanoparticles in food composition separation and food safety detection were reviewed, and the application prospect were discussed.

Publication Date


First Page


Last Page





[1] 郭祖鹏, 师存杰, 焉海波. 磁性纳米材料在分离和检测中的应用研究进展[J]. 磁性材料及器件, 2012, 43(1): 9~19.
[2] 郑磊, 李忠海, 黎继烈. 磁性纳米材料的制备及其应用研究进展[J]. 食品与机械, 2013, 29(1): 255~258.
[3] Indira T K, Lakshmi P K. Magnetic nanoparticles—A review[J]. Int. J. Pharm. Sci. Nanotechnol, 2010, 3(3): 1 035~1 042.
[4] 章建辉, 李莎, 黄辉, 等. 液液萃取—接受相固化—反萃取—气相色谱/质谱法测定奶粉中的香兰素[J]. 食品与机械, 2015, 31(2): 98~101.
[5] Cao Miao, Li Zhong-hong, Wang Jian-long, et al. Food related applications of magnetic iron oxide nanoparticles: Enzyme immobilization, Protein purification, and food analysis[J]. Trends in Food Science & Technology, 2012, 27(1): 47~56.
[6] Yoo J J, Anderson M J, Alligrant T M, et al. Electrochemical detection of insulating beads at subattomolar concentration via magnetic enrichment in a microfluidic device[J]. Analytical Chemistry, 2014, 86(9): 4 302~4 307.
[7] Liu X Y, Zheng S W, Hong R Y, et al. Preparation of magnetic poly (styrene-co-acrylic acid) microspheres with adsorption of protein[J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014, 443(4): 425~431.
[8] Franzreb M, Siemann-Herzberg M, Hobley T J, et al. Protein purification using magnetic adsorbent particles[J]. Applied Microbiology and Biotechnology, 2006, 70(5): 505~516.
[9] Zheng Jin, Ma Chong-jun, Sun Yang-fei, et al. Maltodextrin-modified magnetic microspheres for selective enrichment of maltose binding proteins[J]. ACS Applied Materials & Interfaces, 2014, 6(5): 3 568~3 574.
[10] 杨阳, 钱方, 孙洋, 等. 磁性高分子微球的制备及其在生物领域应用研究进展[J]. 食品与机械, 2014, 30(4): 243~246.
[11] 李桂银, 杨栋梁, 黄可龙, 等. Fe3O4/羧基改性壳聚糖复合纳米粒子的制备, 表征及生物学应用[J]. 功能材料, 2009, 40(7): 1 184~1 187.
[12] 王芳, 韩德艳, 张海丽. 壳聚糖磁性微球的制备及其对牛血清白蛋白的吸附性能研究[J]. 化学与生物工程, 2007, 24(8): 41~44.
[13] Lo Chun-yuen, Chen Wei-yu, Chen Heng-tai, et al. Rapid enrichment of phosphopeptides from tryptic digests of proteins using iron oxide nanocomposites of magnetic particles coated with zirconia as the concentrating probes[J]. Journal of Proteome Research, 2007, 6(2): 887~893.
[14] Wang Meng-yi, Deng Chun-hui, Li Yan, et al. Magnetic binary metal oxides affinity probe for highly selective enrichment of phosphopeptides[J]. ACS Applied Materials & Interfaces, 2014, 6(14): 11 775~11 782.
[15] Zou Zhi-qing, Marta Ibisate, Zhou Yong, et al. Synthesis and evaluation of superparamagnetic silica particles for extraction of glycopeptides in the microtiter plate format[J]. Analytical Chemistry, 2008, 80(4): 1 228~1 234.
[16] Okoli C, Boutonnet M, Mariey L, et al. Application of magnetic iron oxide nanoparticles prepared from microemulsions for protein purification[J]. Journal of Chemical Technology and Biotechnology, 2011, 86(11): 1 386~1 393.
[17] Lin Jenshinn, Lin Yeong-shenn, Kuo Sho-tin, et al. Purification of soybean amylase by superparamagnetic particles[J]. Food Chemistry, 2009, 117(1): 94~98.
[18] 王显祥, 钟娇懿, 刘怡, 等. 磁性荧光双功能纳米材料的合成及其用于葡萄糖的分离检测[J]. 化学学报, 2010, 68(20): 2 063~2 068.
[19] 谢慧明, 李超, 潘见, 等. Fe3O4-PSF 磁性复合超滤膜分离麦冬多糖[J]. 食品科学, 2010, 31(22): 41~45.
[20] Wu Dan, Ma Hong-min, Zhang Yong, et al. Corallite-like magnetic Fe3O4@ MnO2@ Pt nanocomposites as multiple signal amplifiers for the detection of carcinoembryonic antigen[J]. ACS Applied Materials & Interfaces, 2015, 7(33): 18 786~18 793.
[21] Li Xiao-shui, Zhu Gang-tian, Luo Yan-bo, et al. Synthesis and applications of functionalized magnetic materials in sample preparation[J]. TrAC Trends in Analytical Chemistry, 2013, 45(4): 233~247.
[22] Xu Zhou, Ding Li, Long Yan-jiao, et al. Preparation and evaluation of superparamagnetic surface molecularly imprinted polymer nanoparticles for selective extraction of bisphenol A in packed food[J]. Analytical Methods, 2011, 3(8): 1 737~1 744.
[23] 支援, 孟瑾, 郑小平, 等. 一种快速检测阪崎肠杆菌的新方法——免疫磁性分离荧光标记[J]. 乳业科学与技术, 2010, 33(5): 231~233.
[24] Afkhami A, Moosavi R, Madrakian T. Preconcentration and spectrophotometric determination of low concentrations of malachite green and leuco-malachite green in water samples by high performance solid phase extraction using maghemite nanoparticles[J]. Talanta, 2010, 82(2): 785~789.
[25] 张恒, 阳承利, 吕敬章, 等. Fe3O4@ Si-C8/C18 复合磁性纳米材料的制备及其在兽药净化中的应用[J]. 食品科学, 2012, 33(18): 108~112.
[26] Zhai Yun-hui, Duan Shu’e, He Qun, et al. Solid phase extraction and preconcentration of trace mercury (II) from aqueous solution using magnetic nanoparticles doped with 1, 5-diphenylcarbazide[J]. Microchimica Acta, 2010, 169(3/4): 353~360.
[27] Bagheri H, Afkhami A, Saber-Tehrani M, et al. Preparation and characterization of magnetic nanocomposite of Schiff base/silica/magnetite as a preconcentration phase for the trace determination of heavy metal ions in water, food and biological samples using atomic absorption spectrometry[J]. Talanta, 2012, 97(16): 87~95.
[28] Nuria Sanvicens, Carme Pastells, Nuria Pascual, et al. Nanoparticle-based biosensors for detection of pathogenic bacteria[J]. Trends in Analytical Chemistry, 2009, 28(11): 1 243~1 252.
[29] 楚华琴, 卢云峰. 功能化纳米材料的制备及在食品安全检测中的应用研究进展[J]. 分析化学, 2010, 38(3): 442~448.
[30] Yin Hui-qiong, Jia Min-xian, Yang Shu, et al. A nanoparticle-based bio-barcode assay for ultrasensitive detection of ricin toxin[J]. Toxicon, 2012, 59(1): 12~16.
[31] Tang Dian-ping, Liu Bing-qian, Reinhard Niessner, et al. Target-induced displacement reaction accompanying cargo release from magnetic mesoporous silica nanocontainers for fluorescence immunoassay[J]. Food Chemistry, 2013, 85(21): 10 589~10 596.
[32] Xu Jing, Yin Wei-wei, Zhang Yuan-yang, et al. Establishment of magnetic beads-based enzyme immunoassay for detection of chloramphenicol in milk[J]. Food Chemistry, 2012, 134(4): 2 526~2 531.
[33] Vidal J C, Bonel L, Ezquerra A, et al. An electrochemical immunosensor for ochratoxin A determination in wines based on a monoclonal antibody and paramagnetic microbeads[J]. Analytical and Bioanalytical Chemistry, 2012, 403(6): 1 585~1 593.
[34] Zheng Hao-bo, Zhao Qin, Mo Jie-zhen, et al. Quick, easy, cheap, effective, rugged and safe method with magnetic graphitized carbon black and primary secondary amine as adsorbent and its application in pesticide residue analysis[J]. Journal of Chromatography A, 2013, 1 300(14): 127~133.
[35] Deng Xiao-juan, Guo Qian-jin, Chen Xiao-ping, et al. Rapid and effective sample clean-up based on magnetic multiwalled carbon nanotubes for the determination of pesticide residues in tea by gas chromatography-mass spectrometry[J]. Food Chemistry, 2014, 145(7): 853~858.
[36] Suh S H, Dwivedi H P, Jaykus L A. Development and evaluation of aptamer magnetic capture assay in conjunction with real-time PCR for detection of Campylobacter jejuni[J]. LWT-Food Science and Technology, 2014, 56(2): 256~260.
[37] Ma Cui-ping, Wang Wen-shuo, Yang Qing, et al. Cocaine detection via rolling circle amplification of short DNA strand separated by magnetic beads[J]. Biosensors and Bioelectronics, 2011, 26(7):3 309~3 312.
[38] He Jing-lin, Wu Zai-sheng, Zhou Hui, et al. Fluorescence aptameric sensor for strand displacement amplification detection of cocaine[J]. Analytical Chemistry, 2010, 82(4): 1 358~1 364.
[39] Chen Yi-ping, Zou Ming-qiang, Qi Cai, et al. Immunosensor based on magnetic relaxation switch and biotin-streptavidin system for the detection of Kanamycin in milk[J]. Biosensors and Bioelectronics, 2013, 39(1): 112~117.
[40] Yang Hong, Tian Zhi-qing, Wang Juan-juan, et al. A magnetic resonance imaging nanosensor for Hg (II) based on thymidine-functionalized supermagnetic iron oxide nanoparticles[J]. Sensors and Actuators B: Chemical, 2012, 161(1): 429~433.
[41] Shen Jin-chao, Zhang Yang, Yang Hong, et al. Detection of melamine by a magnetic relaxation switch assay with functionalized Fe/Fe3O4 nanoparticles[J]. Sensors and Actuators B: Chemical, 2014(203): 477~482.

Included in

Food Science Commons



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.