To study the effects of blueberry anthocyanin on organ tissue antioxidant activity in experimental diabetic mice. The instreptozotocin-induced diabetic mice were divided into different groups. Diabetic mice were administered for 4 weeks, Malondialdehyde content, the activity of superoxide dismutase and glutathione peroxides, total antioxidant capacity, inhibiting ability of hydroxyl radicals on organ tissue were determined. The experimental data showed that model with blueberry anthocyanin group compared with model control, the content of Malondialdehyde were significantly reduced (P<0.05) while glutathione peroxidase,superoxide dismutase and total antioxidant capacity, inhibiting hydroxyl free radical ability increased markedly in the tissue of all organ (P<0.05). It shows that Blueberry anthocyanin can enhance the cell tissue antioxidant activity.

Publication Date


First Page


Last Page





[1] 李颖畅, 孟宪军, 修英涛, 等. 蓝莓果中花色苷的提取工艺研究[J]. 食品科技, 2007(11): 73-75.
[2] 兰欣, 汪东风, 徐莹, 等. 食品中酚类成分及其与其它充分相互作用研究进展[J]. 食品与机械, 2012, 28(3): 250-254.
[3] WOOD Jacqueline E, SENTHILMOHAN Senti T, PESKIN Alexander V. Antioxidant activity of procyanidin-containing plant extracts at different pH [J]. Food Chemistry, 2002, 7(2): l55-l61.
[4] 李斌, 雷月, 孟宪军, 等. 蓝莓营养保健功能及其活性成分提取技术研究进展[J]. 食品与机械, 2015, 31(6): 251-254.
[5] ANNA R, RENATO C N, DANIELA V, et a1. Modification of glass transition temperature though carbohydrates addition and anthocyanin and soluble phenol stability of frozen blueberry juices [J]. Food Eng., 2003, 56(2/3): 229-231.
[6] HOSSEINIAN F S, BEAT T. Saskatoon and wild blueberries have higher anthocyanin contents than other manitoba berries [J]. Journal of Agricultional and Food Chemistry, 2000, 48(2): 140-146.
[7] FRIA A, OLIVERIAJ, NEVESP, et al. Antioxidant properties of prepared blueberry (Vaccinium myrtillus) extracts [J]. Journal of Agriculture and Food Chemistry, 2005, 53(17): 6 896-6 902.
[8] 李颖畅, 宣景宏, 孟宪军. 蓝莓果中花色素苷的研究进展[J]. 食品研究与开发, 2007, 28(1): 178-180.
[9] 周剑忠, 单成俊, 刘晓莉, 等. 蓝莓复合饮料配方[J]. 江苏农业科学, 2014, 42(10): 236-238.
[10] 刘欢. “浆果之王”蓝莓的营养保健作用研究[J]. 中国新技术新产品, 2009(19): 228.
[11] 赵权, 王军. 山葡萄皮多酚物质的提取工艺[J]. 华北大学学报: 自然科学版, 2009, 10(1): 80-83.
[12] KONG J M, CHIA L S. Analysis and biological activities of anthocyanins[J]. Phytochemistry, 2003, 64(5): 923-933.
[13] STADLER K, JENEI V, VON Bolcshazy G, et al. Role of free radicals and reactive nitrogen species in the late complications of diabetes mellitus rats [J]. Orv Hetil, 2004, 145(21): 1 135-1 140.
[14] 俞璐, 罗敏. 氧化应激与血管并发症[J]. 国外医学: 内分泌学分册, 2005, 26(6): 296-298.
[15] DU Qi-zhen, ZHENG Ju-feng, XU Yong-ji. Composition of anthocyanins in mulberry and their antioxidant activity [J]. Journal of Food composition and Analysis, 2008, 21(5): 390-395.
[16] PNTELIDISGE, VASILANKAKISMG, MANGANARIS A, et al. Antioxidant capacity phenol anthocyanin and ascorbic acid contents in raspberries, blackberries, red currants, gooseberries and comelian cherries [J]. Food Chemistry, 2007, 102(3): 777-783.
[17] 孟宪军, 宋德群, 史琳, 等. 蓝莓花色苷对环磷酰胺致大鼠心脏损伤保护作用[J]. 中国公共卫生, 2015, 31(2): 187-189.
[18] 钟兰兰, 刘进辉, 杨亚, 等. 蔓越莓提取物对高脂大鼠抗氧化损伤的影响[J]. 中国兽医杂志, 2014, 50(1): 48-50.
[19] 田密霞, 李亚东, 胡文忠, 等. 60种蓝莓花青素的含量及抗氧化性的比较研究[J]. 食品研究与开发, 2014, 35(21): 1-5.
[20] 范明霞, 刘新桥, 陈莹, 等. 大孔树脂吸附纯化葡萄籽原花青素的研究[J]. 应用化工, 2009, 38(6): 864-867.
[21] 杨润军, 李青旺, 赵蕊. 四氧嘧啶与链脲佐菌素诱导小鼠糖尿病模型的效果比较[J]. 西北农林科技大学学报, 2006, 32(2): 17-19.
[22] 王金亭, 吴广庆, 杨敏一. 紫荆花红色素对模型动物血糖和血脂的影响研究[J]. 食品工业科技, 2013(13): 330-333.
[23] 梁军, 张志宁, 杨桂珍. 沙棘原花青素对糖尿病小鼠心肌保护作用机制的研究[J]. 长治医学院学报, 2012, 26(2): 91-93.
[24] 彭汉光, 戴春林, 魏屏, 等. 加味四逆散保护肝损伤的实验研究[J]. 中国中医药信息杂志, 2007, 7(11): 25-26.

Included in

Food Science Commons



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.