An efficient microwave assisted extraction procedure for the lignans from the leaves of Cinnamomum camphora was investigated and optimized. Response surface methodology (RSM) based on a three-level four-factor Box Behnken Design (BBD) was employed to optimize the extraction conditions. The best extraction conditions were as follows: microwave time 5 min, ratio of material to ethanol 1∶26 (g/mL), ethanol concentration 80%, microwave temperature 60 ℃. Under the optimization conditions, the experimental yield of lignans was 42.69%, which was well matched with the predictive yield of 42.95%.

Publication Date


First Page


Last Page





[1] RICHA S, TALHA J. Cinnamomum camphora (kapur): review[J]. Pharmacognosy, 2012 , 4(28): 1-5.
[2] HSIEH T J, CHERT C H, LO W L, et al. Lignans from the stem of Cinnamomum camphora[J]. Natural Product Communications, 2006, 1(1): 21-25.
[3] TAKAOKA D, HIROI M, IMOOKA M. Studies of lignoids in Lauraceae Ⅲ: A new lignan from the heart wood of Cinnamomum camphora Sieb [J]. Bulletin of the chemical Society of Japan, 1977, 50(10): 2 821-2 822.
[4] 廖矛川, 杨芳云, 沙光普, 等. 樟树叶化学成分研究[J]. 中国民族大学学报: 自然科学版, 2012, 31(3): 52-55.
[5] 王智慧, 凌铁军, 张梁, 等. 樟树叶化学成分的研究[J]. 天然产物研究与开发, 2014, 26(6): 860-863.
[6] TSOPMO A, AWAH F M, KUETE V. Medicinal plant research in africa [M]. Holand: Academic Press, Elsevier, 2013, 435-478.
[7] CHEN Yu-chen, LIAW C, CHENG Yuan-bin, et al. Anti-liver fibrotic lignans from the fruits of Schisandra arisanensis and Schisandra sphenanthera [J]. Bioorganic and Medicinal Chemistry Letters, 2013, 23: 880-885.
[8] JULIEN S, JACQUES A, PHILIPPE G, et al. Biological activities of lignans and neolignans on the aphid Myzus persicae(Sulzer) [J]. Arthropod Plant Interactions, 2013, 7: 225-233.
[9] KIM K, KIM H, CHOI S, et al. Bioactive lignans from the Rhizomes of Acorus gramineus [J]. Journal of natural products, 2011, 74: 2 187-2 192.
[10] FILLEUR F, POUGET C P, ALLAIS D, et al. Lignans and Neolignans from Myristica Argentea Warb [J]. Nat. Prod. Lett, 2002, 16(1): 1-7.
[11] 高春花, 钟海雁, 孙昌波. 五味子木脂素提取分离和含量测定研究进展[J]. 食品与机械, 2007, 23(1): 151-155.
[12] 夏云麒. 樟叶木脂素的提取及活性研究[D]. 福建: 福建农林大学, 2011: 27-29.
[13] COMIN L M, TEMELLI F, SALDANA M A. Supercritical CO2 extraction of flax lignans [J]. J. Am. Oil Chem. Soc., 2011, 88: 707-715.
[14] 揭广川, 陈红杰, 李必金. 微波辅助复合酶法提取草菇中的风味物质[J]. 食品与机械, 2015, 31(1): 164-167.
[15] 陈韵, 石展望, 黄晓敏. 超声波辅助提取大豆总木脂素及其含量分析[J]. 大豆科学, 2010, 29(1): 168-171.
[16] TAMRESHIA S, MALLIKARJUNAN P, ZHOU Ke-quan, et al. Microwave-assisted extraction of phenolic antioxidant compounds from peanut shins [J]. Food Chemistry, 2010, 120(4): 1 185-1 192.
[17] 谷政伟, 胡铁, 贾媛, 等. 微波辅助提取缬草叶总黄酮工艺研究[J]. 中药材, 2014, 37(1): 2 092-2 095.
[18] 张玉香, 屈慧鸽, 杨润亚, 等. 响应面法优化蓝莓叶黄酮的微波提取工艺[J]. 食品科学, 2010, 31(16): 33-37.
[19] 刘军海, 任惠兰, 官波, 等. 响应面分析法优化黄芪多糖提取工艺[J]. 食品工业, 2008(3): 11-14.
[20] 李梁, 吉建邦, 康效宁, 等. 槟榔花水浸物有效成分提取工艺优化[J]. 食品与机械, 2014, 30(1): 214-219.
[21] MURALIDHAR R V, CHIRUMAMILA R R, MARCHANT R, et al. A response surface approach for the comparison of lipase production by Candida cylindracea using two different carbon sources [J]. Biochem. Eng. J., 2001(9): 17-23.
[22] 宋丽军, 候旭杰, 李雅雯, 等. 核桃青皮中多酚的超高压提取工艺优化[J]. 食品与机械, 2015, 31(4): 178-182.

Included in

Food Science Commons



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.