The application of sodium alginate in enteric hard capsule and carrageenan in gastric hard capsule was clarified in this study. Moreover, the structure and physicochemical properties of the gel and rheology of seaweed polysaccharides compound with other polysaccharides, the film-forming of blended polysaccharides and preparation process of plant hard capsule were also summarized. It was reviewed that the researches and applications of film-forming mechanism in plant hard capsule productions in the present paper. The expectation of the future research direction may provide some strategies to the applications of seaweed polysaccharides plant hard capsules.

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[1] 洪泽淳, 方晓弟, 赵文红, 等. 海藻多糖的研究进展[J]. 农产品加工: 学刊, 2012(8): 93-97.
[2] 魏靖明, 张志斌, 冯华, 等. 海藻酸钠作为药物载体材料的研究进展[J]. 化工新型材料, 2007, 35(8): 20-22.
[3] LIU Bin, WANG Chang-Yun, ZHANG Hong-Rong, et al. New progress in the research on bioactivities and applications of alginate, a kind of marine algal polysaccharide[J]. Chinese Journal of Marine Drugs, 2004, 23(6): 36-41.
[4] 蒋建新. 功能性多糖胶开发与应用[M]. 北京: 中国轻工业出版社, 2013: 86-105
[5] 王秀娟, 张坤生, 任云霞, 等. 海藻酸钠凝胶特性的研究[J]. 食品工业科技, 2008(2): 259-262.
[6] 张楠, 陈海华, 李倩倩, 等. 一种高古罗糖醛酸型海藻酸钠的流变学性质研究[J]. 青岛农业大学学报: 自然科学版, 2015, 32(1): 31-35.
[7] 程晋生. 海藻酸盐和明胶/海藻酸钠混合凝胶[J]. 明胶科学与技术, 2004, 24(4): 169-177.
[8] 王利强, 董晓萌, 游柳青, 等. 海藻酸钠/阿拉伯树胶混合可食性膜液的流变性能[J]. 食品与发酵工业, 2015, 41(4): 73-76.
[9] 刘昌宁, 郝艳玲, 刘瑾瑾. 生物降解复合膜的制备及其性能研究[J]. 中国塑料, 2014(10): 36-39.
[10] 何荣军, 杨爽, 孙培龙, 等. 海藻酸钠/壳聚糖微胶囊的制备及其应用研究进展[J]. 食品与机械, 2010, 26(2): 166-169.
[11] 卢星池, 邓放明, 肖茜. 干燥条件和增塑剂对海藻酸钠——羧甲基纤维素钠膜阻隔性能的影响[J]. 食品与机械, 2014, 30(6): 102-107.
[12] 杜云建, 赵玉巧, 葛宗和, 等. 植物多糖制备药用硬壳胶囊的研究[J]. 安徽农业科学, 2014, 42(27): 9 540-9 543.
[13] 张东, 高昕, 许加超, 等. 褐藻胶植物肠溶硬胶囊的制备技术[J]. 食品工业科技, 2011(3): 321-323.
[14] 郭卫强, 唐鹤生. 新型海洋植物硬空心胶囊的研制[J]. 食品与机械, 2012, 28(1): 235-237.
[15] 张青. 褐藻胶钙离子交联体系肠溶空心硬胶囊制备技术[D]. 青岛: 中国海洋大学, 2013: 33-38.
[16] CHANG Pong-Chih, DOBASHI T. Preparation of alginate complex capsules containing eucalyptus essential oil and its controlled release[J]. Colloids & Surfaces B Biointerfaces, 2003, 32(3): 257-262.
[17] 刘芳, 赵谋明. 卡拉胶与其它多糖类协同作用机理的研究进展[J]. 食品科学, 2000, 21(4): 8-13.
[18] 苏生显, 许永安. 红藻胶的理化特性及应用研究进展[J]. 现代农业科技, 2013(10): 279-280.
[19] 王志辉, 李春海. κ-卡拉胶凝胶特性的研究[J]. 江苏食品与发酵, 2008(4): 4-5.
[20] 刘国军, 盛龙, 童群义. 普鲁兰多糖对κ-卡拉胶凝胶特性及流变学性质的影响[J]. 食品工业科技, 2014, 35(4): 148-152.
[21] ARDA E, KARA S, PEKCAN . Synergistic effect of the locust bean gum on the thermal phase transitions of κ-carrageenan gels[J]. Food Hydrocolloids, 2009, 23(2): 451-459.
[22] LAFARGUE D, LOURDIN D, DOUBLIER J L. Film-forming properties of a modified starch/κ-carrageenan mixture in relation to its rheological behaviour[J]. Carbohydrate Polymers, 2007, 70(1): 101-111.
[23] TOMICˇ M, PROSSNIGG F, GLATTER O. A thermoreversible double gel: Characterization of a methylcellulose and κ -carrageenan mixed system in water by SAXS, DSC and rheology[J]. Journal of Colloid & Interface Science, 2008, 322(1): 41-50.
[24] KU M S, LI Wei-yi, DULIN W, et al. Performance qualification of a new hypromellose capsule: Part I. Comparative evaluation of physical, mechanical and processability quality attributes of Vcaps Plus○R, Quali-V○R and gelatin capsules[J]. International Journal of Pharmaceutics, 2010, 386(386): 30-41.
[25] KUA M Sherry, LU Qing-Hong, LI Wei-Yi, et al. Performance qualification of a new hypromellose capsule: Part II. Disintegration and dissolution comparison between two types of hypromellose capsules[J]. International Journal of Pharmaceutics, 2011, 416(1): 16-24.
[26] 张小菊, 姜发堂. 植物硬空心胶囊成型工艺研究[J]. 食品科技, 2008, 33(12): 60-62.
[27] 吴佩, 张秀梅, 李婷, 等. 海藻多糖复合胶成膜性研究[J]. 海洋与湖沼, 2010, 41(1): 148-153.
[28] FAKHARIAN M H, TAMIMI N, ABBASPOUR H, et al. Effects of κ-carrageenan on rheological properties of dually modified sago starch: Towards finding gelatin alternative for hard capsules[J]. Carbohydrate Polymers, 2015, 132: 156-163.
[29] MISSAGHI S, FASSIHI R. Evaluation and comparison of physicomechanical characteristics of gelatin and hypromellose capsules[J]. Drug Development & Industrial Pharmacy, 2006, 32(7): 829-838.
[30] BRIONES A V, AMBAL W O, ESTRELLA R R, et al. Tensile and tear strength of carrageenan film from philippine eucheuma species[J]. Marine Biotechnology, 2004, 6(2): 148-151.
[31] 韩丽君, 史大永, 袁毅, 等. 海藻多糖植物胶囊生产专用胶: 中国, 200810016403.X[P]. 2008-11-05.
[32] 邵自强. 新型药物胶囊——植物胶囊的制备方法: 中国, 200610169632.6[P]. 2007-08-29.
[33] 梁贤昌. 一种植物空心胶囊和软胶囊组合物及其制备方法: 中国, 200910261415.3[P]. 2010-05-19.
[34] 许自霖. 一种海藻胶体的植物胶囊组合物及其制备方法: 中国, 201410044359.9[P]. 2014-05-07.
[35] 韩字光. 植物空心胶囊及其制法: 中国, 201410450102.3[P]. 2014-09-05.
[36] 朱桂波. 植物胶囊用复合胶及其制备方法: 中国, 201210265235.4[P]. 2014-07-30.
[37] FAKHOURI F M, MARTELLI S M, CAON T, et al. Edible films and coatings based on starch/gelatin: Film properties and effect of coatings on quality of refrigerated red crimson grapes[J]. Postharvest Biology & Technology, 2015, 109: 57-64.
[38] PAN Hong-yang, BO Jiang, CHEN Jie, et al. Assessment of the physical, mechanical, and moisture-retention properties of pullulan-based ternary co-blended films[J]. Carbohydrate Polymers, 2014, 112(112): 94-101.
[39] MESBAH A, VERSYPT A N F, ZHU Xiao-xiang, et al. Nonlinear model-based control of thin-film drying for continuous pharmaceutical manufacturing[J]. Industrial & Engineering Chemistry Research, 2013, 53(18): 7 447-7 460.
[40] BISPO J A C, BONAFE C F S, SANTANA K M O V, et al. Nanoring arrays on fe coated substrate: formation and guidance for the growth of hierarchical CNTs[J]. Langmuir, 2015, 60(1): 192-198.
[41] RAMANA S, LUCAS S F, ANAGHA B, et al. Fast drying of biocompatible polymer films loaded with poorly water-soluble drug nano-particles via low temperature forced convection[J]. International Journal of Pharmaceutics, 2013, 455(1/2): 93-103.
[42] ZHANG Wei, YANG Fut K, HAN You-gun, et al. Surface and tribological behaviors of the bioinspired polydopamine thin films under dry and wet conditions[J]. Biomacromolecules, 2013, 14(2): 394-405.



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