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Abstract

As the core of the miniaturized total analysis system, microfluidic chip has the characteristics of high efficiency separation, rapid analysis, low reagent consumption and miniaturization, provides a new platform for rapid detection analysis. With the development of microfluidic technology, paper based microfluidic chip has been widely used because of its low cost, easy fabrication and convenient carrying. This paper mainly introduces the processing technology of paper based microfluidic chip, including wax printing method, UV lithography and plasma processing technology, inkjet printing technology and wax dipping technology, cutting technology and the application of paper-based microfluidic chip.

Publication Date

8-28-2017

First Page

204

Last Page

209

DOI

10.13652/j.issn.1003-5788.2017.08.044

References

[1] MANZ A, GRABER N, WIDMER H M. Miniaturized total chemical analysis systems: A novel concept for chemical sensing[J]. Sensors and Actuators B: Chemical, 1990, 1(1/2/3/4/5/6): 244-248.
[2] BRUZEWICZ D A, RECHES M, WHITESIDES G M. Low-cost printing of poly(dimethylsiloxane) barriers to define microchannels in paper[J]. Analytical Chemistry, 2008, 80(9): 3 387-3 392.
[3] 董娅妮, 方群. 微流控芯片毛细管电泳在蛋白质分离分析中的应用研究进展[J]. 色谱, 2008, 26(3): 269-273.
[4] HOSSAIN S M Zakir, LUCKHAM Roger E, MCFADDEN Meghan J, et al. Reagentless bidirectional lateral flow bioactive paper sensors for detection of pesticides in beverage and food samples[J]. Analytical Chemistry,2009, 81(21): 9 055-9 064.
[5] NOGAMI T, HASHIMOTO M, TSUKAGOSHI K. Metal ion analysis using microchip CE with chemiluminescence detection based on 1,10-phenanthroline-hydrogen peroxide reaction[J]. Journal of Separation Science, 2009, 32(3): 408-412.
[6] XIA Yan-yan, SI Jin, LI Zhi-yang. Fabrication techniques for microfluidic paper-based analytical devices and their applications for biological testing: A review[J]. Biosensors & Bioelectronics, 2016, 77: 774-789.
[7] LI Ying, QI Wang. Microfluidic chip-based technologies: emerging platforms for cancer diagnosis[J]. BMC Biotechnology, 2013, 13(1): 1-10.
[8] LEE J W, LEE D, KIM Y T, et al. Low-cost and facile fabrication of a paper-based capillary electrophoresis microdevice for pathogen detection[J]. Biosensors and Bioelectronics, 2017, 91: 388-392.
[9] ALI M M, AGUIRRE S D, XU Y, et al. Detection of DNA using bioactive paper strips[J]. Chemical Communications, 2009(43): 6 640-6 642.
[10] YANG Xiao-xi, OMID F, THEODORE P B, et al. Integrated separation of blood plasma from whole blood for microfluidic paper-based analytical devices[J]. Lab on a Chip, 2012, 12(2): 274-280.
[11] 薛媛媛. 食源性致病沙门氏菌的纸基微流控芯片检测研究[D]. 西安: 西北农林科技大学, 2016: 35-46.
[12] JIANG Yan, MA Cui-cui, HU Xian-qiao, et al. Fabrication techniques of microfluidic paper-based chips and their applications[J]. Progress in Chemistry, 2014, 26(10): 167-177.
[13] 金鑫. 一种快速制作纸基微流控芯片的方法及其在生化传感中的应用[D]. 长沙: 湖南大学, 2016: 47-52.
[14] RATTANARAT P, DUNGCHAI W, CATE D, et al. Multilayer paper-based device for colorimetric and electrochemical quantification of metals[J]. Analytical Chemistry, 2014, 86(7): 3 555-3 562.
[15] ZHONG Z W, WANG Z P, HUANG G X D. Investigation of wax and paper materials for the fabrication of paper-based microfluidic devices[J]. Microsystem Technologies, 2012, 18(5): 649-659.
[16] CARRILHO E, MARTINEZ A W, WHITESIDES G M G G H E. Understanding wax printing: A simple micropatterning process for paper-based microfluidics[J]. Analytical Chemistry, 2009, 81(16): 7 091-7 095.
[17] 王方方, 陈锦, 何治柯. 纸芯片制作及其在化学发光法检测葡萄糖和尿酸中的应用[J]. 分析科学学报, 2011(2): 137-141.
[18] 马日红. 基于SU-8紫外光刻工艺的直流微电铸技术研究[D]. 哈尔滨: 哈尔滨工业大学, 2013: 11-25.
[19] MARTINEZ A W, PHILLIPS S T. Patterned paper as a platform for inexpensive, low-volume, portable bioassays[J]. Angewandte Chemie (International Edition in English), 2007, 46(8): 1 318-1 320.
[20] MARTINEZ A W, PHILLIPS S T, WILEY B J, et al. FLASH: a rapid method for prototyping paper-based microfluidic devices[J]. Lab on a Chip, 2008, 8(12): 2 146-2 150.
[21] HALLER P D, FLOWERS C A, GUPTA M. Three-dimensional patterning of porous materials using vapor phase polymerization[J]. Soft Matter, 2011, 7(6): 2 428-2 432.
[22] HE Qiao-hong, MA Cui-cui, HU Xian-qiao, et al. Method for fabrication of paper-based microfluidic devices by alkylsilane self-assembling and UV/O3-patterning[J]. Analytical chemi-stry, 2013, 85(3): 1 327-1 331.
[23] KAO P-K, HSU C-C. One-step rapid fabrication of paper-based microfluidic devices using fluorocarbon plasma polymerization[J]. Microfluidics and Nanofluidics, 2014, 16(5): 811-818.
[24] 严春芳, 余思扬, 蒋艳, 等. 基于等离子体技术制作微流控纸芯片及其在血糖检测中的应用研究[J]. 化学学报, 2014(10): 1 099-1 104.
[25] FENTON E M, MASCARENAS M R, LOPEZ G P, et al. Multiplex lateral-flow test strips fabricated by two-dimensional shaping[J]. ACS Applied Materials and Interfaces, 2008(1): 124-129.
[26] YU Jun-ho, JEONG S G, LEE C S, et al. Fabrication of a paper-based analytical device for multiple colorimetric analysis via inkjet-printing and paper-cutting[J]. BioChip Journal, 2015, 9(2): 139-143.
[27] XU Li, TIAN Jun-fei, GARNIER G, et al. Fabrication of paper-based microfluidic sensors by printing[J]. Colloids and Surfaces B: Biointerfaces, 2010, 76(2): 564-570.
[28] CASSANO C L, FAN Z H. Laminated paper-based analytical devices (LPAD): fabrication, characterization, and assays[J]. Microfluidics and Nanofluidics, 2013, 15(2): 173-181.
[29] SONG J T, DUNG C W, CHAILA P O, et al. Novel, simple and low-cost alternative method for fabrication of paper-based microfluidics by wax dipping[J]. Talanta, 2011, 85(5): 2 587-2 593.
[30] GIRISH Chitnis, DING Zhen-wen, CHANG Chun-li, et al. Laser-treated hydrophobic paper: an inexpensive microfluidic platform[J]. Lab on a Chip, 2011, 11(6): 1 161.
[31] NIE Jin-fang, ZHANG Yun, LIN Li-wen, et al. Low-cost fabrication of paper-based microfluidic devices by one-step plotting[J]. Analytical Chemistry, 2012, 84(15): 6 331-6 335.
[32] MOHAMMAD A T, SHEN Wei, ZEINEDDINE R, et al. Validation of Paper-Based Assay for Rapid Blood Typing[J]. Analytical Chemistry, 2012, 84(3): 1 661-1 668.
[33] VELLA S J, BEATTIE P, CADEMARTIRI R, et al. Measuring markers of liver function using a micropatterned paper device designed for blood from a fingerstick[J]. Analytical Chemistry, 2012, 84(6): 2 883-2 891.
[34] ARENA A, DONATO N, SAITTA G, et al. Flexible ethanol sensors on glossy paper substrates operating at room temperature[J]. Sensors and Actuators B, 2010, 145(1): 488-494.
[35] LI Xu, TIAN Jun-fei, SHEN Wei. Progress in patterned paper sizing for fabrication of paper-based microfluidic sensors[J]. Cellulose, 2010, 17(3): 649-659.
[36] JOKERST J C, ADKINS J A, BISHA B, et al. Development of a paper-based analytical device for colorimetric detection of select foodborne pathogens[J]. Analytical Chemistry, 2012, 84(6): 2 900-2 907.
[37] 肖良品, 刘显明, 刘启顺. 用于亚硝酸盐快速检测的三维纸质微流控芯片的制作[J]. 食品科学, 2013(22): 341-345.
[38] 窦斌. 基于微流控芯片和SERS的瘦肉精类物质检测[D]. 大连: 大连理工大学, 2014: 28-43.
[39] HOSSAIN S M Z, LUCKHAM R E, MCFADDEN M J, et al. Reagentless bidirectional lateral flow bioactive paper sensors for detection of pesticides in beverage and food samples[J]. Analytical Chemistry, 2009, 81(21): 9 055-9 064.
[40] ZHANG Meng, GE Lei, GE Shen-guang, et al. Three-dimensional paper-based electrochemiluminescence device for simultaneous detection of Pb(2+) and Hg(2+) based on potential-control technique[J]. Biosensors & Bioelectronics, 2013, 41: 544-550.
[41] WANG Hu, LI Ya-jie, WEI Jun-feng, et al. Paper-based three-dimensional microfluidic device for monitoring of heavy metals with a camera cell phone[J]. Analytical and Bioanalytical Chemistry, 2014, 406(12): 2 799-2 807.

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