•  
  •  
 

Abstract

The gelatin-pullulan composite films were prepared. Then the properties of composite films were determined to provide a direction to evaluate the performance of hard capsules, optimize the ratio between capsule materials, and reduce the brittleness and water vapor permeability (WVP). The compatibility between gelatin and pullulan was characterized by light transmittance, Fourier transform infrared spectroscopy and scanning electron microscopy. The results indicated that it could be used for the blending modification of gelatin hard capsules when the glycerol addition was 10% (dry basis percentage), and the mass ratio between gelatin and pullulan was 9∶1. The WVP of the composite films, prepared by the above conditions, was reduced by 26% compared with that of the gelatin films. The elongation at break was 1.19 times higher than the level of gelatin films in low humidity environment. There was good compatibility between the molecules of gelatin and pullulan in the composite films, which could explain the improvement of mechanical stability, and the reduction of WVP.

Publication Date

5-28-2019

First Page

137

Last Page

143

DOI

10.13652/j.issn.1003-5788.2019.05.025

References

[1] 姚龙坤. 药用明胶质量对胶囊安全性的影响[J]. 明胶科学与技术, 2006, 26(4): 204-207.
[2] 李承献. 明胶在胶囊中的应用(一)[J]. 明胶科学与技术, 2012, 32(1): 40-46.
[3] 王跃猛. 明胶—矿物质空也硬胶囊壳的研制[D]. 天津: 天津科技大学, 2014: 1-7.
[4] 张青. 褐藻胶钙离子交联体系肠溶空心硬胶囊制备技术[D]. 青岛: 中国海洋大学, 2013: 1-22.
[5] 王丽媛, 侯梦奇, 李晓, 等. 4种改性方式对明胶膜性能的影响[J]. 食品科学, 2015, 36(6): 40-44.
[6] 丁丁. 淀粉—明胶共混法改性明胶硬胶囊[J]. 明胶科学与技术, 2014, 34(1): 1-8.
[7] CIPER M, BODMEIER R. Modified conventional hard gelatin capsules as fast disintegrating dosage form in the oral cavity[J]. European Journal of Pharmaceutics and Biopharnwiceutics, 2006, 62(2): 178-184.
[8] 余家会, 杜予民, 郑化. 壳聚糖—明胶共混膜[J]. 武汉大学学报: 自然科学版, 1999, 45(4): 440-444.
[9] ROBERT S, SINT N, DOMINQUE C, et al. Pullulan film compositions: US, 006887307B1[P]. 2005-05-03.
[10] 刘国军. 普鲁兰多糖—卡拉胶基硬胶囊囊材的研究[D]. 无锡: 江南大学, 2014: 38-53.
[11] 高丹丹, 徐学玲, 江连洲, 等. 普鲁兰多糖—明胶可食性膜的特性[J]. 食品科学, 2014, 35(1): 69-73.
[12] 张东. 褐藻胶肠溶空心硬胶囊制备技术研究[D]. 青岛: 中国海洋大学, 2010: 18-32.
[13] 路春玲, 冯强, 陈虹, 等. 一次性成型肠溶空心胶囊的制备及性能测试[J]. 中国药学杂志, 2015, 50(23): 2 057-2 063.
[14] 国家药典委员委员会. 中国药典: 四部[M]. 北京: 北京化学工业出版社, 2015: 522.
[15] 姚遥, 肖满, 严文莉, 等. 魔芋葡甘聚糖—普鲁兰多糖复合膜的制备与性能研究[J]. 食品工业科技, 2016, 37(18): 312-315.
[16] WANG Zhe, SUN Xiu-xiu, LIAN Zi-xuan, et al. The effects of ultrasonic/microwave assisted treatment on the properties of soy protein isolate /microcrystalline wheat-bran cellulose film[J]. Journal of Food Engineering, 2013, 114(2): 183-191.
[17] 高丹丹, 张超, 马越, 等. 甘油对明胶—普鲁兰多糖复合材料性能的影响[J]. 食品研究与开发, 2013, 34(10): 108-111.
[18] 马慧婷. 低酰基结冷胶/明胶复合食用膜的制备、性能与应用研究[D]. 杭州: 浙江工商大学, 2018: 17-22.
[19] LIU Fei, CHIOU B S, AVENA R J, et al. Study of combined effects of glycerol and transglutaminase on properties of gelatin films[J]. Food Hydrocolloids, 2017, 65: 1-9.
[20] CHO S W, ULLSTEN H, GALLSTEDT M, et al. Heat-sealing properties of compression-molded wheat gluten films[J]. Journal of Biobased Material and Bioenergy, 2007, 1(1): 56-63.
[21] TONG Qun-yi, XIAO Qian, LIM L T. Preparation and properties of pullulan-alginate-carboxymethylcellulose blend films[J]. Food Research International, 2008, 41(10): 1 007-1 014.
[22] ZHU Gui-lan, SHENG Long, TONG Qun-yi. Preparation and characterization of carboxymethyl-gellan and pullulan blend films[J]. Food Hydrocolloids, 2014, 35: 341-347.
[23] VALENZUELA C, ABUGOCH L, TAPIA C. Quinoa protein-chitosan-sunflower oil edible film: mechanical, barrier and structural properties[J]. LWT-Food Science and Technology, 2013, 50(2): 531-537.
[24] TONGNUANCHAN P, BENJAKUL S, PRODPRAN T. Structural, morphological and thermal behaviour characterisations of fish gelatin film incorporated with basil and citronella essential oils as affected by surfactants[J]. Food Hydrocolloids, 2014, 41(1): 33-43.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.