•  
  •  
 

Abstract

In this study, an inter-standard quantitative method was used for determination of PAHs in gum-based chewing tobacco by GC-MS/MS. Under the control of the optimized experimental conditions, the LODs and the LOQs of 19 target PAHs could achieve 0.04~0.14 ng/mL and 0.14~0.46 ng/mL, respectively, while the linear correlation efficiencies were larger than 0.998 for all PAHs. With three different adding-levels, the recovery rates for all PAHs ranging from 92.26% to 109.46%. And the Intra-assay and Inter-assay precisions for the PAHs were 0.77%~3.85% and 1.57%~4.86%, respectively. The method developed was reliable and suitable for routine analysis of PAHs, and was verified to be one of the effective methods for quality control of gum-based chewing tobacco.

Publication Date

5-28-2020

First Page

89

Last Page

94

DOI

10.13652/j.issn.1003-5788.2020.05.017

References

[1] FOULDS J,RAMSTROM L,BURKE M,et al.Effect of smokeless tobacco(snus)on smoking a public health in Sweden[J].Tobacco Control,2003,12(4):349-359.
[2] BATES C,FAGERSTROM K,JARVISM J,et al.European Union policy on smokeless tobacco:A statement in favour of evidence based regulation for public health[J].Tobacco Control,2003,12(4):360-367.
[3] RICKERT W S,JOZA P J,TRIVEDI A H,et al.Chemical and toxicological characterization of commercial smokeless tobacco products available on the Canadian market[J].Regulatory Toxicology and Pharmacology,2009,53(2):121-133.
[4] RICHTER P,HODGE K,STANFILL S,et al.Surveillance of moist snuff:Total nicotine,moisture,pH,un-ionized nicotine,and tobacco-specific nitrosamines[J].Nicotine & Tobacco Research,2008,10(11):1 645-1 652.
[5] 周昆,王超,杨继,等.模拟溶出法研究胶基型嚼烟烟碱在口腔中的释放行为[J].烟草科技,2018,51(10):71-76,96.
[6] 韩敬美,汤建国,袁大林,等.HS/GC-MS法分析胶基型嚼烟中的挥发性香味物质[J].分析测试学报,2016,35(8):1 005-1 009.
[7] 王丁众,李鹏,张启东,等.UPLC-HRMS法测定无烟气烟草制品中的小分子醛[J].烟草科技,2018,51(1):43-49.
[8] 张杰,王兆宇,李鹏,等.无烟气烟草制品中TSNAs的分析研究[J].中国烟草学报,2012(5):1-8.
[9] 张杰,李鹏,宗永立,等.国外口含型无烟气烟草制品总烟碱、游离烟碱和烟草特有亚硝胺含量分析[J].烟草科技,2011(10):44-48.
[10] 张洪非,李雪,姜兴益,等.一种在线固相萃取高效液相色谱测定无烟气烟草制品中多环芳烃的方法:中国,201510561591.4[P].2015-12-09.
[11] 张杰,李鹏,孙世豪,等.GC/MS法同时检测无烟气烟草制品中的1,2-丙二醇、丙三醇和三甘醇[J].烟草科技,2011(3):36-42.
[12] 张东豫,李鹏,朱琦,等.电感耦合等离子体质谱法同时测定口胶基型嚼烟中7种重金属元素[J].食品安全质量检测学报,2016(10):4 179-4 186.
[13] 安社娟,陈家垄,陈学敏.多环芳烃致癌的分子毒理学研究进展[J].国外医学:卫生学分册,2005,32(1):10-13.
[14] 胡碧清,叶佳,李倩莲,等.基于共价有机骨架-MSPE-HPLC-UV法测定多环芳烃[J].食品与机械,2019,35(11):64-69,197.
[15] HECHT S S.Tobacco smoke carcinogens and lung canc-er[J].Journal of the National Cancer Institute,1999,91(14):1 194-1 210.
[16] 何智慧,练文柳,罗嘉,等.选择性降低卷烟烟气中苯并芘含量的研究[J].现代科学仪器,2006(1):76-77.
[17] 刘晓晨,齐琳,杨波,等.大连地区6种贝类体内苯并(a)芘和3-羟基苯并芘含量测定[J].中国卫生检验杂志,2013(5):1 243-1 244,1 247.
[18] ARIMILLI S,DAMRATOSKI B E,BOMBICK B,et al.Evaluation of cytotoxicity of different tobacco product preparations[J].Regulatory Toxicology and Pharmacology,2012,64(5):350-360.
[19] COGGINS M,BALLANTYNE M,CURVALL M,et al.The in vitro toxicology of Swedish snus[J].Toxicology Letters,2012,42(4):304-313.
[20] WHO.WHO framework convention on tobacco control:Control and prevention of smokeless tobacco products and electronic cigarettes\[EB/OL\].(2010-09-15)\[2017-02-26\].http://apps.who.int/iris/handle/10665/75749.
[21] 蔡洁云,王惠平,陈新瑞,等.GC-MS/MS法快速测定卷烟主流烟气中苯并\[a\]芘的含量[J].云南民族大学学报:自然科学版,2018,27(2):95-101.
[22] 刘春波,申钦鹏,张凤梅,等.在线液相—气相二维色谱测定卷烟主流烟气中的苯并\[a\]芘[J].分析化学,2016(2):241-246.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.