Assessment of the edible safety of licorice oil

Authors

DOU Kang-ning, Henan Engineering Research Center of Leisure Food, Luohe Medical College, Luohe, Henan 462002, China
DONG Bin, Henan Kening Biological Technology Co., Ltd., Zhengzhou, Henan 450000, China

Abstract

The toxicology of licorice oil was researched through the acute toxicity test of mice, genotoxicity test of mouse sperm deformity and subacute toxicity test, and made a safety evaluation on it. The experimental results showed that the acute oral LD₅₀ of licorice oil on mice was greater than 15.0 g/kg·BW, which was classified as non-toxic. The mouse sperm deformity genetic toxicity test was negative, indicating that the test substance had no mutagenic effect. No abnormal changes in animal health status, biochemistry, hematology indexes and organ tissue morphology were observed in the 30-day feeding experiment. Based on this, it was estimated that the maximum non-effective dose of the product was greater than 5.0 g/kg·BW, which was 150 times as high as the recommended human intake. Therefore, licorice oil had no acute toxicity, subacute toxicity and genotoxicity, and licorice oil was excellent edible oil with higher safety.

Publication Date

2-28-2021

First Page

24

Last Page

27,232

DOI

10.13652/j.issn.1003-5788.2021.02.005

Recommended Citation

Kang-ning, DOU and Bin, DONG (2021) "Assessment of the edible safety of licorice oil," Food and Machinery: Vol. 37: Iss. 2, Article 5.
DOI: 10.13652/j.issn.1003-5788.2021.02.005
Available at: https://www.ifoodmm.cn/journal/vol37/iss2/5

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