Abstract
Objective: This study aimed to investigate the effect of Antarctic krill oil on zebrafish model of depression. Methods: The zebrafish (Danio rerio) model of depression was induced by 40 mg/L reserpine, and five groups, i.e., blank control group, model group, fluoxetine group, low-dose krill oil group and high-dose krill oil group were investigated and compared, buy using new tank test (NTT) and light dark box test (LDB). The central nervous system serotonin (5-HT), dopamine (DA), monoamine oxidase A (MAO-A) Interleukin-6 (IL-6), tumor necrosis factor α (TNF-α) and systemic cortisol (COR) levels of the five groups were analyzed. Results: Reserpine 40 mg/L caused depressive behavior in zebrafish, while the addition of prawn oil reduced the this behavior, by increasing the levels of monoamine neurotransmitters including 5-HT and DA in the brain and decreasing the levels of MAO-A, IL-6 and TNF-α proinflammatory factors and systemic COR levels. Conclusion: Antarctic krill oil can improve the depression of zebrafish by reducing neuroinflammation and regulating neuroendocrine.
Publication Date
10-20-2023
First Page
152
Last Page
156,171
DOI
10.13652/j.spjx.1003.5788.2022.81050
Recommended Citation
Meng-jie, GUO; Yun, LIU; Zhi-qiang, WU; and Guo-liang, JIANG
(2023)
"Improvement of Antarctic krill oil on reserpine induced zebrafish depression model,"
Food and Machinery: Vol. 39:
Iss.
7, Article 23.
DOI: 10.13652/j.spjx.1003.5788.2022.81050
Available at:
https://www.ifoodmm.cn/journal/vol39/iss7/23
References
[1] HERRMAN H, PATEL V, KIELING C, et al. Time for united action on depression: A lancet-world psychiatric association commission[J]. The Lancet, 2022, 399（2）: 957-1 022.
[2] 尹一淑, 刘军莲, 王佳平, 等. 抑郁症相关发病机制研究进展[J]. 医学综述, 2022, 28（12）: 2 368-2 372.
YIN Y S, LIU J L, WANG J P, et al. Research progress in pathogenesis of depression[J]. Medical Recapitulate, 2022, 28（12）: 2 368-2 372.
[3] CARVALHO A F, SHARMA M S, BRUNONIA R, et al. The safety, tolerability and risks associated with the use of newer generation antidepressant drugs: A critical review of the literature[J]. Psychotherapy and Psychosomatics, 2016, 85（5）: 270-288.
[4] COLLETTI A, CRAVOTTO G, CITIV, et al. Advances in technologies for highly active omega-3 fatty acids from krill oil: Clinical applications[J]. Marine Drugs, 2021, 19（6）: 1-30.
[5] 吴永祥, 雍张, 王茵, 等. 鳜鱼内脏副产物中鱼油的精炼及其品质分析[J]. 食品与机械, 2022, 38 （9）: 204-210.
WU Y X, YONG Z, WANG Y, et al. Refining and quality analysis of fish oil in byproducts of mandarin fish viscera[J]. Food & Machinery, 2022, 38 （9）: 204-210.
[6] BURRI L. Krill oil supplementation and cognitive function[M]// MARTIN C R, PREEDY V R. Diet and nutrition in dementia and cognitive decline. San Diego: Academic Press, 2015: 1 031-1 038.
[7] Sanjay,PARK M, LEE H J. Roles of fatty acids in microglial polarization: Evidence from in vitro and in vivo studies on neurodegenerative diseases[J]. International Journal of Molecular Sciences, 2022, 23（13）: 1-28.
[8] GU M, LI X, YAN L,et al. Endogenous ω-3 fatty acids in fat-1 mice attenuated depression-like behaviors, spatial memory impairment and relevant changes induced by olfactory bulbectomy[J]. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2021, 171（7）: 1-10.
[9] 陈彦婕, 唐嘉诚, 宫萱, 等. 鱼油提取、多不饱和脂肪酸富集及EPA和 DHA的应用研究进展[J]. 食品与机械, 2021, 37（11）: 205-210.
CHEN Y J, TANG J C, GONG X, et al. Research progress on fish oil extraction, polyunsaturated fatty acid enrichment and application of EPA and DHA[J]. Food & Machinery, 2021, 37（11）: 205-210.
[10] VAN DER WURFF I S M, VON SCHACKY C, BERGELAND T, et al. Effect of one year krill oil supplementation on depressive symptoms and self-esteem of Dutch adolescents: A randomized controlled trial[J]. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2020, 163（1）: 1-9.
[11] LOGAN AC. Omega-3 fatty acids and major depression: A primer for the mental health professional[J]. Lipids in Health and Disease, 2004, 3（1）: 1-8.
[12] BATETTA B, GRIINARI M, CARTA G, et al. Endocannabinoids may mediate the ability of （n-3） fatty acids to reduce ectopic fat and inflammatory mediators in obese zucker rats[J]. The Journal of Nutrition, 2009, 139（8）: 1 495-1 501.
[13] PUTTONEN H A J, SEMENOVA S, SUNDVIKM, et al. Storage of neural histamine and histaminergic neurotransmission is VMAT2 dependent in the zebrafish[J]. Scientific Reports, 2017, 7（1）: 30-60.
[14] OSTADKARAMPOUR M, PUTNINSE. Monoamine oxidase inhibitors: A review of their anti-inflammatory therapeutic potential and mechanisms of action[J]. Frontiers in Pharmacology, 2021, 16（12）: 1-17.
[15] 赵传凯, 姜国良, 赵静, 等. 南极大磷虾油脂的提取及其脂肪酸组成分析[J]. 食品工业科技, 2012, 33 （3）: 207-209.
ZHAO C K, JIANG G L, ZHAO J, et al. Extraction of oil from Antarctic krill and analysis of its fatty acid composition[J]. Science and Technology of Food Industry, 2012, 33（3）: 207-209.
[16] KYZAR E, STEWART A M, LANDSMAN S, et al. Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish[J]. Brain Research, 2013, 1 527: 108-116.
[17] MARCON M, HERRMANN A P, MOCELINR, et al. Prevention of unpredictable chronic stress-related phenomena in zebrafish exposed to bromazepam, fluoxetine and nortriptyline[J]. Psychopharmacology, 2016, 233: 3 815-3 824.
[18] FONSEKA T M, WEN X, FOSTERJ A, et al. Zebrafish models of major depressive disorders[J]. Journal of Neuroscience Research, 2016, 94（1）: 3-14.
[19] LACHOWICZ J, NIEDZIAEK K, ROSTKOWSKAE, et al. Zebrafish as an animal model for testing agents with antidepressant potential[J]. Life, 2021, 11（8）: 1-19.
[20] CAIO M, THIAGO M D B, CLAUDIO ALBERTO GELLIS DE MATTOSD, et al. Scototaxis as anxiety-like behavior in fish[J]. Nature Protocols, 2010, 5（2）: 209-216.
[21] MAXIMINO C, BRITO T, BATISTA A, et al. Measuring anxiety in zebrafish: A critical review[J]. Behavioural Brain Research, 2010, 214（2）: 157-171.
[22] MAXIMINO C, DA SILVA A W B, GOUVEIA A, et al. Pharmacological analysis of zebrafish （Danio rerio） scototaxis[J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2011, 35（2）: 624-631.
[23] MENDOZA C, PEREZ-URRUTIA N, ALVAREZ-RICARTESN, et al. Cotinine plus krill oil decreased depressive behavior, and increased astrocytes survival in the hippocampus of mice subjected to restraint stress[J]. Frontiers in Neuroscience, 2018, 12（12）: 1-11.
[24] WIBRAND K, BERGE K, MESSAOUDIM, et al. Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats[J]. Lipids in Health and Disease, 2013, 12（1）: 1-13.
[25] MARIANI N, EVERSON J, PARIANTE C M, et al. Modulation of microglial activation by antidepressants[J]. Journal of Psychopharmacology, 2022, 36（2）: 131-150.
[26] ANDRAKA J M, SHARMA N, MARCHALANT Y. Can krill oil be of use for counteracting neuroinflammatory processes induced by high fat diet and aging?[J]. Neuroscience Research, 2020, 157（16）: 1-14.
[27] WOHLEB E S, GODBOUT J P. Basic aspects of the immunology of neuroinflammation[J]. Inflammation in Psychiatry, 2013, 28（2）: 1-19.
[28] PARIANTEC M. Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation[J]. European Neuropsychopharmacology, 2017, 27（6）: 554-559.
[29] KELLER J, GOMEZ R, WILLIAMS G, et al. HPA axis in major depression: Cortisol, clinical symptomatology and genetic variation predict cognition[J]. Molecular Psychiatry, 2017, 22（4）: 527-536.
[30] MAXIMINO C, PUTY B, BENZECRYR, et al. Role of serotonin in zebrafish （Danio rerio） anxiety: Relationship with serotonin levels and effect of buspirone, WAY 100635, SB 224289, fluoxetine and para-chlorophenylalanine （pCPA） in two behavioral models[J]. Neuropharmacology, 2013, 3（6）: 83-97.
[31] TANG Y, FAN Z, YANGM, et al. Low concentrations of the antidepressant venlafaxine affect courtship behaviour and alter serotonin and dopamine systems in zebrafish （Danio rerio）[J]. Aquatic Toxicology, 2022, 244（10）: 60-82.
[32] KOPSCHINA FELTES P, DOORDUIN J, KLEIN HC, et al. Anti-inflammatory treatment for major depressive disorder: Implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy[J]. Journal of Psychopharmacology, 2017, 31（9）: 1 149-1 165.
[33] NGUYEN M, STEWART A M, KALUEFF A V. Aquatic blues: Modeling depression and antidepressant action in zebrafish[J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2014, 55（12）: 26-39.