Anti-fatigue effect of food-derived compound ginseng aqueous extracts

Authors

XIONG Wuqing, School of Pharmacy , Guizhou University of Traditional Chinese Medicine , Guiyang , Guizhou 550025 , China
MA Xiuping, School of Pharmacy , Guizhou University of Traditional Chinese Medicine , Guiyang , Guizhou 550025 , China ;National Engineering and Technology Research Centre for Miao Medicine , Guiyang , Guizhou 550025 , China ;Guizhou Engineering and Technology Research Centre for Chinese Medicine Concoction and Preparation , Guiyang , Guizhou 550025 , China ;Research Centre for Tea and Healthy Foods Development , Guizhou University of Traditional Chinese Medicine , Guiyang , Guizhou 550025 , ChinaFollow
GUO Jiangtao, School of Pharmacy , Guizhou University of Traditional Chinese Medicine , Guiyang , Guizhou 550025 , China ;Research Centre for Tea and Healthy Foods Development , Guizhou University of Traditional Chinese Medicine , Guiyang , Guizhou 550025 , China
BAI Zhiwen, Research Centre for Tea and Healthy Foods Development , Guizhou University of Traditional Chinese Medicine , Guiyang , Guizhou 550025 , China ;Guizhou Wucha Healthy Industry Development Co., Ltd., Guiyang , Guizhou 550002 , China
LUO Shixi, School of Pharmacy , Guizhou University of Traditional Chinese Medicine , Guiyang , Guizhou 550025 , China

Corresponding Author(s)

麻秀萍（1971—），女，贵州中医药大学教授，学士。E-mail：mxp001130@sina.com

Abstract

［Objective］ To investigate the anti -fatigue effect of compound aqueous extracts of Ginseng Radix et Rhizoma,Polygonati Rhizoma,Polygonati Odorati Rhizoma,and Citri Reticulatae Pericarpium in mice.［Methods］ The experiment included a blank control group,a positive control group (Rhodiola rosea capsules,0.70 g/kg ),and low,medium,and high dose groups of compound ginseng aqueous extracts (1.56,3.30,and 6.60 g/kg,respectively ),which were administered by gavage for 30 days.The anti -fatigue effect was evaluated using the weight -bearing exhaustion swimming test and by measuring biochemical markers,including hepatic glycogen,blood lactate,and blood urea nitrogen.［Results］ Compared with the blank control group,the compound ginseng aqueous extracts had no significant effect on the normal weight gain or mental state of the mice (P>0.05).The medium and high dose groups significantly prolonged the swimming time during weight -bearing exhaustion (P<0.05).The high dose group significantly increased hepatic glycogen levels (P<0.05) and reduced blood lactate,blood urea nitrogen,and malondialdehyde levels (P<0.05).［Conclusion］ The compound ginseng aqueous extracts help alleviate exercise -induced fatigue in mice and demonstrate strong anti -fatigue effect.

Publication Date

4-3-2025

First Page

180

Last Page

185

DOI

10.13652/j.spjx.1003.5788.2024.80835

Recommended Citation

Wuqing, XIONG; Xiuping, MA; Jiangtao, GUO; Zhiwen, BAI; and Shixi, LUO (2025) "Anti-fatigue effect of food-derived compound ginseng aqueous extracts," Food and Machinery: Vol. 41: Iss. 1, Article 23.
DOI: 10.13652/j.spjx.1003.5788.2024.80835
Available at: https://www.ifoodmm.cn/journal/vol41/iss1/23

References

[1] LUO C H,XU X R,WEI X C,et al.Natural medicines for the treatment of fatigue:bioactive components,pharmacology,and mechanisms [J].Pharmacological Research,2019,148:104409.
[2] LIU G Y,YANG X,ZHANG J X,et al.Synthesis,stability and anti-fatigue activity of selenium nanoparticles stabilized by Lycium barbarum polysaccharides [J].International Journal of Biological Macromolecules,2021,179:418-428.
[3] 甘昌胜,王珊珊,李鸿,等.复方红景天缓解体力疲劳活性的研究 [J].食品与生物技术学报,2019,38(8):134-141.GAN C S,WANG S S,LI H,et al.Study on the anti-fatigue activity of the compound of rhodiola [J].Journal of Food Science and Biotechnology,2019,38(8):134-141.*表示与 C组比较差异显著 （P<0.05）|[4] 嵇晶,张云羽,王令充,等.基于经典名方的药食同源大健康产品开发应用探讨 [J].南京中医药大学学报,2023,39(9):961-966.JI J,ZHANG Y Y,WANG L C,et al.Development of big health products based on classic famous prescriptions and homology of medicine and food [J].Journal of Nanjing University of Traditional Chinese Medicine,2023,39(9):961-966.
[5] LU G Y,LIU Z T,WANG X,et al.Recent advances in Panax ginseng C.A.Meyer as a herb for anti-fatigue:an effects and mechanisms review [J].Foods,2021,10(5):1 030.
[6] 李彦力,苏艺,袁晚晴,等.黄精主要活性成分、功能及其作用机制研究进展 [J].现代食品科技,2023,39(12):354-363.LI Y L,SU Y,YUAN W Q,et al.Advances in characterizing the main active components,functions,and mechanisms of polygonatum species [J].Modern Food Science and Technology,2023,39(12):354-363.
[7] 牛友芽.玉竹多糖对小鼠的抗疲劳作用 [J].天然产物研究与开发,2018,30(7):1 202-1 207.NIU Y Y.Effects of Polygonatum odoratum polysaccharide on anti-fatigue in mice [J].Natural Product Research and Development,2018,30(7):1 202-1 207.
[8] 姜雨桐,赵垠旭,姜昊轩,等.黄精及其药对配伍应用浅析 [J].河南中医,2022,42(9):1 435-1 440.JIANG Y T,ZHAO Y X,JIANG H X,et al.An analysis of the compatibility application of Huangjing and its drug pairs [J].Henan Traditional Chinese Medicine,2022,42(9):1 435-1 440.
[9] 曹佳璐,张华宇,郑冰元,等.人参—玉竹药对改善抑郁伴认知障碍机制研究 [J].时珍国医国药,2024,35 (13):2 939-2 945.CAO J L,ZHANG H Y,ZHENG B Y,et al.Ginseng and polygonatum medicine for improving mechanisms of depression with cognitive impairment [J].Lishizhen Medicine and Materia Medica Research,2024,35 (13):2 939-2 945.
[10] 沈龙宇,朱昕昀,胡宇,等.异功散中人参皂苷类成分在脾虚大 鼠 模 型 肠 吸 收 动 力 学 变 化 及 其 陈 皮 的 影 响 [J].世 界 科 学技术—中医药现代化,2024,26(5):1 298-1 307.SHEN L Y,ZHU X Y,HU Y,et al.Changes in intestinal absorption kinetics of ginsenosides in Yi Gong San in the rat model of spleen deficiency and its effect of pericarpium citri reticulatae [J].Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology,2024,26(5):1 298-1 307.
[11] 睢博文,马翠霞,苗磊,等.复方人参健体方的处方优化及其抗 疲 劳 活 性 和 急 性 毒 性 研 究 [J].中 国 药 房,2020,31(8):926-932.SUI B W,MA C X,MIAO L,et al.Formulation optimization of compound Renshen Jianti formulation and study on its anti-fatigue activity and acute toxicity [J].China Pharmacy,2020,31(8):926-932.
[12] 黄彩云,何吉福,宋春虹,等.当归多糖抗运动疲劳作用及其机制研究 [J].康复学报,2022,32(5):434-440.HUANG C Y,HE J F,SONG C H,et al.Study on anti-fatigue effect and mechanism of angelica sinensis polysaccharide [J].Rehabilitation Medicine,2022,32(5):434-440.[13] 李娟,张一唱,崔光红,等.九香虫提取物的抗疲劳和补肾壮阳 活 性 评 价 [J].中 南 民 族 大 学 学 报 (自 然 科 学 版 ),2018,37(2):45-48.LI J,ZHANG Y C,CUI G H,et al.Evaluation of anti-fatigue and aphrodisiac activity of extract from aspongopus chinensis[J].Journal of South-Central University for Nationalities (Natural Science Edition ),2018,37(2):45-48.
[14] ZOU X X,YOKOYAMA W,LIU X H,et al.Milk fat globule membrane relieves fatigue via regulation of oxidative stress and gut microbiota in BALB/c mice [J].Antioxidants,2023,12(3):712.
[15] 李祥坤,曾亦菡.响应面优化霍山石斛百香果复合饮料工艺及 抗 运 动 疲 劳 研 究 [J].中 国 食 品 添 加 剂,2023,34(1):272-281.LI X K,ZENG Y H.Optimization of compound beverage of Dendrobium huoshanense and passion fruit by response surface method and its anti-fatigue effect [J].China Food Additives,2023,34(1):272-281.
[16] CHEN Y,WANG J J,JING Z H,et al.Anti-fatigue and anti-oxidant effects of curcumin supplementation in exhaustive swimming mice via Nrf 2/Keap 1 signal pathway [J].Current Research in Food Science,2022,5:1 148-1 157.
[17] 李欣.鹿茸菇多糖对小鼠抗疲劳能力的影响 [J].食品研究与开发,2022,43(16):44-50.LI X.Anti-fatiuge effects of lyophyllum decastes polysaccharides in mice [J].Food Research and Development,2022,43(16):44-50.
[18] GUAN T Y,LI S S,GUAN Q J,et al.Spore powder of Paecilomyces hepiali shapes gut microbiota to relieve exercise-induced fatigue in mice [J].Nutrients,2022,14(14):2 973.
[19] 刘志青,王飞,颜冬梅,等.基于多指标优化巴西人参复方提取 工 艺 及 其 抗 疲 劳 研 究 [J].中 药 材,2022,45(10):2 452-2 456.LIU Z Q,WANG F,YAN D M,et al.Optimisation of the extraction process of Brazilian ginseng compound and its anti-fatigue effects based on multiple indicators [J].Journal of Chinese Medicinal Materials,2022,45(10):2 452-2 456.
[20] ZHOU S S,ZHOU J,XU J D,et al.Ginseng ameliorates exercise-induced fatigue potentially by regulating the gut microbiota [J].Food & Function,2021,12(9):3 954-3 964.
[21] WANG X,QU Y D,ZHANG Y F,et al.Antifatigue potential activity of Sarcodon imbricatus in acute excise-treated and chronic fatigue syndrome in mice via regulation of Nrf 2-mediated oxidative stress [J].Oxidative Medicine and Cellular Longevity,2018,2 018:9140896.
[22] 韩燕燕,吴巍,王悦宏,等.人参山羊奶粉缓解体力疲劳作用及 其 标 志 性 成 分 含 量 测 定 [J].食 品 工 业 科 技,2020,41(19):20-25,32.HAN Y Y,WU W,WANG Y H,et al.Evaluation of ginseng-goat milk powder on anti-fatigue effect and quantitative analysis of its functional components [J].Science and Technology of Food Industry,2020,41(19):20-25,32.