Simultaneous determination of 10 neonicotinoid pesticides in raw milk by ultra-high performance liquid chromatography tandem mass spectrometry

Authors

GAO Mengfeng, Shanghai Center of Agri-product Quality and Safety , Shanghai 201708 , China ;Food Quality Supervision and Inspection Center of Ministry of Agriculture and Rural Affairs (Shanghai ), Shanghai 201708 , China
TONG Jinrong, Shanghai Center of Agri-product Quality and Safety , Shanghai 201708 , China ;Food Quality Supervision and Inspection Center of Ministry of Agriculture and Rural Affairs (Shanghai ), Shanghai 201708 , China
MEI Bo, Shanghai Center of Agri-product Quality and Safety , Shanghai 201708 , China ;Food Quality Supervision and Inspection Center of Ministry of Agriculture and Rural Affairs (Shanghai ), Shanghai 201708 , China
WANG Xia, Shanghai Center of Agri-product Quality and Safety , Shanghai 201708 , China ;Food Quality Supervision and Inspection Center of Ministry of Agriculture and Rural Affairs (Shanghai ), Shanghai 201708 , China
ZHANG Weiyi, Shanghai Center of Agri-product Quality and Safety , Shanghai 201708 , China ;Food Quality Supervision and Inspection Center of Ministry of Agriculture and Rural Affairs (Shanghai ), Shanghai 201708 , ChinaFollow

Corresponding Author(s)

张维谊（1977—），女，上海市农产品质量安全中心推广研究员，硕士。E-mail：zhangharewei@163.com

Abstract

［Objective］ To establish an analysis method for the simultaneous determination of 10 neonicotinoid pesticide residues in raw milk by dispersive solid -phase extraction combined with ultra -high performance liquid chromatography -tandem mass spectrometry (UPLC -MS).［Methods］ The samples are extracted with acetonitrile,salted out with a QuECHER salt pocket,and purified by the dispersive solid -phase extraction (d-SPE) method.The analytes are detected by UPLC -MS/MS and quantified by the external standard method.［Results］ 10 targeted compounds show a good linear relationship in a certain concentration range with the coefficient of determination (R2) over 0.999.The limits of detection (LODs ) are 0.2~0.5 μg/kg,while the limits of quantification (LOQs ) are 1.0 μg/kg.At the supplemental levels of 1.0,2.5,and 5.0 μg/kg,the average recovery rates of standard addition of analytes in raw milk are between 75.9%~108.9%,with the intra -day precision (RSDr) of 1.8%~7.6% and the inter -day precision (RSDR) less than 11.7%.［Conclusion］ The established method is simple for pretreatment and has good repeatability and high sensitivity.It is suitable for the detection of neonicotinoid pesticide residues in raw milk.

Publication Date

4-3-2025

First Page

74

Last Page

79

DOI

10.13652/j.spjx.1003.5788.2023.80346

Recommended Citation

Mengfeng, GAO; Jinrong, TONG; Bo, MEI; Xia, WANG; and Weiyi, ZHANG (2025) "Simultaneous determination of 10 neonicotinoid pesticides in raw milk by ultra-high performance liquid chromatography tandem mass spectrometry," Food and Machinery: Vol. 41: Iss. 1, Article 9.
DOI: 10.13652/j.spjx.1003.5788.2023.80346
Available at: https://www.ifoodmm.cn/journal/vol41/iss1/9

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