In vivo antioxidant activity of exogenous glutathione on aging mice

Authors

WANG Ming, Anhui Zhengxing Biopharmaceutical Technology Co ., Ltd., Xuancheng , Anhui 242000 , China
YU Yongming, Anhui Zhengxing Biopharmaceutical Technology Co ., Ltd., Xuancheng , Anhui 242000 , China
WANG Yuhui, College of Biological Science and Technology , Beijing Forestry University , Beijing 100083 , China ;Beijing Key Laboratory of Forest Food Processing and Safety , Beijing 100083 , China
ZHANG Shuaijia, College of Biological Science and Technology , Beijing Forestry University , Beijing 100083 , China ;Beijing Key Laboratory of Forest Food Processing and Safety , Beijing 100083 , China
LUO Yao, College of Biological Science and Technology , Beijing Forestry University , Beijing 100083 , China ;Beijing Key Laboratory of Forest Food Processing and Safety , Beijing 100083 , China
MA Chao, College of Biological Science and Technology , Beijing Forestry University , Beijing 100083 , China ;Beijing Key Laboratory of Forest Food Processing and Safety , Beijing 100083 , ChinaFollow

Corresponding Author(s)

马超（1979—），男，北京林业大学教授，博士。E-mail：machao@bjfu.edu.cn

Abstract

[Objective] To investigate the effect of exogenous glutathione (GSH ) on improving antioxidant capacity in aging mice. [Methods] Aging mice were administered GSH by gavage at different doses (166. 7, 83. 3, and 41. 7 mg/kg ) continuously for 30 days. Levels of malondialdehyde (MDA ), 8-isoprostane, protein carbonyl (PCO ), and reduced GSH in serum and liver homogenate, as well as activities of total superoxide dismutase (T-SOD ) and glutathione peroxidase (GSH-PX), were measured. [Results] Compared with the blank control group, the high-dose GSH group showed significant reductions in MDA and PCO levels, increased T-SOD activity in serum, and elevated reduced GSH content in aging mice (P<0.05). No adverse effects on body weight gain or organ indices were observed. [Conclusion] GSH effectively improves oxidative stress status during the aging process.

Publication Date

11-19-2025

First Page

126

Last Page

131

DOI

10.13652/j.spjx.1003.5788.2025.80080

Recommended Citation

Ming, WANG; Yongming, YU; Yuhui, WANG; Shuaijia, ZHANG; Yao, LUO; and Chao, MA (2025) "In vivo antioxidant activity of exogenous glutathione on aging mice," Food and Machinery: Vol. 41: Iss. 10, Article 17.
DOI: 10.13652/j.spjx.1003.5788.2025.80080
Available at: https://www.ifoodmm.cn/journal/vol41/iss10/17

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