Research progress on the molecular mechanisms and structure-activity relationships of Morchella esculenta polysaccharides in immune regulation

Authors

ZHOU Yangjie, College of Food Science , Southwest University , Chongqing 400715 , China
MING Jian, College of Food Science , Southwest University , Chongqing 400715 , China ;Research Center for Fruits and Vegetables Logistics Preservation and Nutritional Quality Control , Southwest University , Chongqing 400715 , China ;Chongqing Key Laboratory of Specialty Food Co-Built by Sichuan and Chongqing , Chongqing 400715 , ChinaFollow
RAO Zhenan, College of Food Science , Southwest University , Chongqing 400715 , China
HE Ying, College of Food Science , Southwest University , Chongqing 400715 , China
LEI Xiaojuan, College of Food Science , Southwest University , Chongqing 400715 , China ;Research Center for Fruits and Vegetables Logistics Preservation and Nutritional Quality Control , Southwest University , Chongqing 400715 , China ;Chongqing Key Laboratory of Specialty Food Co-Built by Sichuan and Chongqing , Chongqing 400715 , China
ZHAO Jichun, College of Food Science , Southwest University , Chongqing 400715 , China ;Research Center for Fruits and Vegetables Logistics Preservation and Nutritional Quality Control , Southwest University , Chongqing 400715 , China ;Chongqing Key Laboratory of Specialty Food Co-Built by Sichuan and Chongqing , Chongqing 400715 , China

Corresponding Author(s)

明建（1972—），男，西南大学教授，博士。E-mail：mingjian1972@163.com

Abstract

Morchella esculenta is a precious edible and medicinal fungus,rich in active substances such as polyphenols,polypeptides and polysaccharides. M.esculenta polysaccharides (MEP) are a class of carbohydrates formed by the polymerization of aldose or ketose through glycosidic bonds,exhibiting a variety of biological activities including immune regulation,hypolipidemic effects,and anti-fatigue properties. With the deepening of research,the market demand for MEP is constantly increasing,making it particularly important to optimize its extraction and purification processes. Immune regulation is a key process in living organisms,and as the main active ingredient,MEP has attracted significant attention for its immunoregulatory function. However,its specific mechanism of action and structure-activity relationships remain unclear. This study reviews different extraction and purification methods of MEP,as well as the structural differences and immunoregulatory activity mechanisms of polysaccharides,and analyzes the structure-activity relationships.

Publication Date

1-13-2026

First Page

171

Last Page

179

DOI

10.13652/j.spjx.1003.5788.2025.80550

Recommended Citation

Yangjie, ZHOU; Jian, MING; Zhenan, RAO; Ying, HE; Xiaojuan, LEI; and Jichun, ZHAO (2026) "Research progress on the molecular mechanisms and structure-activity relationships of Morchella esculenta polysaccharides in immune regulation," Food and Machinery: Vol. 41: Iss. 12, Article 21.
DOI: 10.13652/j.spjx.1003.5788.2025.80550
Available at: https://www.ifoodmm.cn/journal/vol41/iss12/21

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