Abstract
［Objective］ To explore the differences in cytotoxicity,antioxidant,and hypoglycemic activities of resveratrol,oxy -resveratrol,and piceatannol,three stilbene compounds with similar structures.［Methods］ The cytotoxicity,extracellular/intracellular antioxidant activity,and hypoglycemic activity of the three compounds are analyzed by Cell Counting Kit -8 (CCK -8),total antioxidant activity,cellular antioxidant stress ability,intracellular reactive oxygen species (ROS ) content,cellular antioxidant activity (CAA ) assay,and α-glucosidase inhibitory activity.［Results］］ Compared with oxy -resveratrol and resveratrol,piceatannol shows lower cytotoxicity,better extracellular antioxidant activity,and α-glucosidase inhibitory activity.All three stilbenes effectively mitigate the oxidative stress damage of HepG 2 cells induced by H2O2 solution and reduce the ROS content in HepG 2 cells in a dose -dependent manner.Oxy -resveratrol demonstrates a stronger capacity to inhibit the generation of oxygen free radicals induced by ABAP in HepG 2 cells.［Conclusion］ The three stilbene compounds all have high antioxidant activity and hypoglycemic activity.
Publication Date
6-2-2025
First Page
130
Last Page
138
DOI
10.13652/j.spjx.1003.5788.2024.80706
Recommended Citation
Ying, CHEN; Chaobing, ZHANG; Shaoqiang, CHEN; Rian, YAN; and Yongsheng, CHEN
(2025)
"Comparison of cytotoxicity , antioxidation and hypoglycemic activity of three stilbene compounds,"
Food and Machinery: Vol. 41:
Iss.
4, Article 16.
DOI: 10.13652/j.spjx.1003.5788.2024.80706
Available at:
https://www.ifoodmm.cn/journal/vol41/iss4/16
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