Abstract
［Objective］ To prepare metal complexes of biochanin A (BA) and explore their biological activities.［Methods］ Biochanin A was used as the ligand to design and synthesize biochanin A -copper (BA-Cu),biochanin A -zinc (BA-Zn),and biochanin A -chromium (BA-Cr) metal complexes.The structures of the complexes were characterized using methods such as ultraviolet spectroscopy and infrared spectroscopy.The antioxidant activities of the three biochanin A metal complexes were evaluated using the phosphomolybdate complex method,and their anticancer activities were assessed using the CCK -8 assay.［Results］］ The experiments successfully prepared the three biochanin A metal complexes,i.e.,BA-Cu,BA-Zn,and BA -Cr.All three metal complexes exhibited good antioxidant activities,which were higher than those of the ligand biochanin A and the positive control drug BHT.Among them,BA-Cr exhibited the best antioxidant activity.The three biochanin A metal complexes inhibited the proliferation of human lung cancer A 549 cells,cervical cancer Hela cells,and breast cancer MCF -7 cells,with overall inhibitory effects greater than those of the ligand biochanin A.Among them,BA-Zn demonstrated the best anticancer activity.［Conclusion］ The three biochanin A metal complexes,BA-Cu,BA-Zn,and BA -Cr,were successfully prepared.Among them,BA-Cr exhibited the best antioxidant activity,while BA -Zn demonstrated the best anticancer activity.
Publication Date
7-3-2025
First Page
190
Last Page
195
DOI
10.13652/j.spjx.1003.5788.2024.81003
Recommended Citation
Youdi, WANG; Yingming, LUO; Junxiang, GUO; Jie, CHEN; Bin, YAN; and Juanjuan, XU
(2025)
"Preparation and bioactivity of biochanin A metal complexes,"
Food and Machinery: Vol. 41:
Iss.
6, Article 26.
DOI: 10.13652/j.spjx.1003.5788.2024.81003
Available at:
https://www.ifoodmm.cn/journal/vol41/iss6/26
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