Abstract
［Objective］ To study the effect of walnut oil on lipid metabolism and elucidate its mechanism of action.［Methods］ A high -fat diet is used to establish a high -fat model of SD rats,and 500,1 000,and 1 500 mg/kg undiluted walnut oil is used for gavage intervention experiments.After 8 weeks of intervention,the changes in body weight,organ indexes,serum lipid biochemical indicators,and serum antioxidant related indicators of SD rats are measured to observe the effects of walnut oil on organs,blood lipids,and antioxidant capacity.The expression of ABCA 1 mRNA,ABCG 1 mRNA,and SREBP 2-HMGCR signaling pathway and PPAR α-LXRα-CYP 7A1 signaling pathway genes in rat liver are measured by using the QPCR method to explore the mechanism by which walnut oil regulates liver cholesterol metabolism.［Results］］ Compared with the high -fat model group,walnut oil can significantly reduce the body weight and liver index of SD rats (P<0.05),but has no effect on the heart index,kidney index,and spleen index.Walnut oil significantly reduces TC,TG,and LDL in the serum of SD rats (P<0.05).It can also significantly increase HL and LPL content to regulate LDL and HDL (P<0.05).In addition,walnut oil significantly increases the content of SOD,GSH -Px,CAT,and T -AOC (P<0.05) and significantly reduces the content of MDA (P<0.05).Walnut oil significantly upregulates the expression of ABCA 1 mRNA and ABCG 1 mRNA (P<0.05),downregulates the expression of SREBP 2 mRNA and HMGCR mRNA,and upregulates the expression of PPAR α mRNA,LXRα mRNA and CYP 7A1 mRNA.引用格式：谢珊珊，陈文礼，崔澍春.核桃油的降血脂作用及其机制 ［J］.食品与机械，2025，41（7）：168-174.C itation:XIE Shanshan,CHEN Wenli,CUI Shuchun.Lipid-lowering effect and mechanism of walnut oil [J].Food & Machinery,2025,41(7):168-174.|［Conclusion］ Walnut oil can reduce serum TC levels by reducing liver TC biosynthesis and enhancing liver TC cell uptake,decomposition,and excretion and also improves the imbalance of the antioxidant system by increasing the expression of antioxidant system enzymes.
Publication Date
7-11-2025
First Page
168
Last Page
174
DOI
10.13652/j.spjx.1003.5788.2024.81158
Recommended Citation
Shanshan, XIE; Wenli, CHEN; and Shuchun, CUI
(2025)
"Lipid-lowering effect and mechanism of walnut oil,"
Food and Machinery: Vol. 41:
Iss.
7, Article 22.
DOI: 10.13652/j.spjx.1003.5788.2024.81158
Available at:
https://www.ifoodmm.cn/journal/vol41/iss7/22
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