Abstract
[Objective] To explore the mechanism by which procyanidin B2 (PB2) intervenes in inflammation and insulin resistance (IR) through multi-target modulation. [Methods] The potential of PB 2 in diabetes prevention was evaluated via in vitro antioxidant assays, and molecular biology techniques were used to reveal the regulatory effect of PB 2 on the NF-κB inflammatory signaling pathway during the progression of IR. [Results] PB2 significantly reduced reactive oxygen species (ROS) levels in HepG 2 cells by scavenging free radicals and inhibited the expression of inflammatory factors IL-6, IL-1β, and TNF-α. By suppressing the JNK/NF-κB signaling cascade, PB2 blocked excessive ROS production, thereby restoring intracellular redox homeostasis and ultimately improving insulin resistance. [Conclusion] PB2 can regulate glucose metabolism and antagonize inflammatory responses by modulating redox balance and inflammatory signaling pathways.
Publication Date
9-25-2025
First Page
143
Last Page
148
DOI
10.13652/j.spjx.1003.5788.2025.80395
Recommended Citation
Wenli, YANG; Si, QIN; Chenghao, LU; Yixue, WANG; and Shiyun, CHEN
(2025)
"Antioxidant and anti-inflammatory activities and molecular mechanisms of procyanidin B 2,"
Food and Machinery: Vol. 41:
Iss.
8, Article 19.
DOI: 10.13652/j.spjx.1003.5788.2025.80395
Available at:
https://www.ifoodmm.cn/journal/vol41/iss8/19
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