Abstract
[Objective] To investigate the protective effect of Haematococcus pluvialis (H.pluvialis) powder on lipopolysaccharide (LPS)-induced oral epithelial damage. [Methods] The effects of different doses of H.pluvialis on the viability of human oral keratinocytes (HOKs) were assessed. In LPS-induced HOKs, changes in the tight junction-associated proteins ZO-1 and Occludin, mitochondrial morphology, reactive oxygen species (ROS), mitochondrial membrane potential (MMP), mitochondrial superoxide (MitoSOX), and mitochondrial permeability transition pore (MPTP) were evaluated. [Results] Compared with the LPS model group, high-dose H.pluvialis significantly upregulated the expression levels of Occludin and ZO-1 to 151.56% and 170.52%, respectively (P < 0.05), and promoted their membrane localization. In addition, H.pluvialis markedly improved LPS-induced excessive ROS and MitoSOX production, the reduction in MMP, and the increase in MPTP in HOKs. [Conclusion] H.pluvialis may alleviate LPS-induced barrier damage in HOKs by improving mitochondrial dysfunction and reducing oxidative stress, suggesting its potential as a functional food for oral mucosal barrier repair.
Publication Date
10-28-2025
First Page
137
Last Page
146
DOI
10.13652/j.spjx.1003.5788.2024.80971
Recommended Citation
Jinmei, XIE; Cailian, CHEN; Yong, ZHANG; Yunjian, ZHENG; and Xi, XIE
(2025)
"Ameliorating effect of Haematococcus pluvialis powder on LPS-induced barrier damage in HOK cells,"
Food and Machinery: Vol. 41:
Iss.
9, Article 18.
DOI: 10.13652/j.spjx.1003.5788.2024.80971
Available at:
https://www.ifoodmm.cn/journal/vol41/iss9/18
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