Effects of wrinkled pea meal replacement powder on glucose and lipid metabolism disorders and gut microbiota in mice

Authors

• CUI Yajun, Beijing Food Additives Engineering and Technology Research Centre , School of Food and Health , Beijing Technology and Business University , Beijing 100048 , China
• HONG Lingyu, Beijing Food Additives Engineering and Technology Research Centre , School of Food and Health , Beijing Technology and Business University , Beijing 100048 , China
• ZHOU Sumei, Beijing Food Additives Engineering and Technology Research Centre , School of Food and Health , Beijing Technology and Business University , Beijing 100048 , China
• HE Yuhua, Institute of Grain Crops , Yunnan Academy of Agricultural Sciences , Kunming , Yunnan 650201 , China
• YAO Yang, Institute of Crop Science , Chinese Academy of Agricultural Sciences , Beijing 100081 , China
• HOU Dianzhi, Beijing Food Additives Engineering and Technology Research Centre , School of Food and Health , Beijing Technology and Business University , Beijing 100048 , ChinaFollow

Corresponding Author(s)

侯殿志（1989—），男，北京工商大学副教授，博士。E-mail：houdianzhi@btbu.edu.cn

Abstract

［Objective］ To investigate the effects of wrinkled pea meal replacement powder on glucose and lipid metabolism disorders and gut microbiota.［Methods］ A 12-week intervention experiment was conducted using a high-fat diet-fed mouse model. Changes in key indicators,including mouse phenotypes,blood biochemical parameters, histopathology, and gut microbial composition, were systematically monitored.［Results］ Wrinkled pea meal replacement powder significantly reduced fasting blood glucose, area under the blood glucose curve, and serum levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol in high-fat-fed mice (P<0.05). It effectively alleviated hepatic steatosis, reduced serum alanine aminotransferase levels (P<0.05), and significantly mitigated hepatocyte damage. Additionally, consumption of wrinkled pea meal replacement powder significantly regulated gut microecological imbalance induced by a high-fat diet, increased gut microbial richness, decreased the Firmicutes/Bacteroidetes ratio, and increased the relative abundance of beneficial bacteria, including norank_f_ Muribaculaceae, norank_o_ Clostridia _UCG- 014, and Bifidobacterium.［Conclusion］ Wrinkled pea meal replacement powder has potential application value in improving glucose and lipid metabolism and regulating gut health.

Publication Date

6-17-2026

First Page

158

Last Page

168

DOI

10.13652/j.spjx.1003.5788.2026.80086

Recommended Citation

Yajun, CUI; Lingyu, HONG; Sumei, ZHOU; Yuhua, HE; Yang, YAO; and Dianzhi, HOU (2026) "Effects of wrinkled pea meal replacement powder on glucose and lipid metabolism disorders and gut microbiota in mice," Food and Machinery: Vol. 42: Iss. 5, Article 19.
DOI: 10.13652/j.spjx.1003.5788.2026.80086
Available at: https://www.ifoodmm.cn/journal/vol42/iss5/19

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