Abstract
［Objective］ To explore the repairing effect of Sipunculus nudus collagen peptide (SNCP ) on skin wounds and clarify its potential efficacy in anti -inflammation, oxidative stress regulation,and wound repair promotion.［Methods］ Collagen is extracted from the body wall of S.nudus via the hot water extraction method, and SNCP is subsequently prepared through enzymolysis and ultrafiltration. Then,the lipopolysaccharide (LPS)-induced RAW 264.7 cell inflammation model and the whole cortex wound inflammation model in mice are employed to detect the effect of SNCP on cytotoxicity and cell morphology, as well as the inflammatory, antioxidant, and growth factors in mouse wound tissues.［Results］ At 50 to 400 μg/mL, SNCP exhibits no cytotoxicity, significantly improves the LPS-induced abnormal cell morphology, and effectively reduces nitric oxide (NO) level, demonstrating potent in vitro anti-inflammatory activity. Additionally, SNCP significantly improves the wound healing rate in the whole mouse cortex. By downregulating tumor necrosis factor -α (TNF -α), interleukin -1β (IL-1β), and interleukin -6 (IL-6) levels, SNCP upregulates catalase (CAT ) and superoxide dismutase (SOD ) activities, thus promoting fibroblast growth factor (FGF ), transforming growth factor -β1 (TGF -β1), and vascular endothelial growth factor (VEGF ) expression. These collective actions alleviate the inflammatory response, mitigate oxidative stress injury, ultimately promoting wound healing.［Conclusion］ SNCP demonstrates anti-inflammation and skin wound repair promotion activities.
Publication Date
6-17-2026
First Page
181
Last Page
188
DOI
10.13652/j.spjx.1003.5788.2025.80521
Recommended Citation
Haoyang, HUANG; Junyi, ZHANG; Weiqiang, SHEN; Wenhong, CAO; and Haisheng, LIN
(2026)
"Anti-inflammatory effect of Sipunculus nudus collagen peptide and its mechanism in skin wound repair promotion in mice,"
Food and Machinery: Vol. 42:
Iss.
5, Article 21.
DOI: 10.13652/j.spjx.1003.5788.2025.80521
Available at:
https://www.ifoodmm.cn/journal/vol42/iss5/21
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