Abstract
Veterinary drug residues constitute a global challenge that poses significant threats to food safety and public health. This review systematically summarizes recent advances in detection technologies for veterinary drug residues in food, with a particular focus on the performance characteristics and application status of sample extraction techniques (including liquid-liquid extraction, solid phase extraction, accelerated solvent extraction, QuEChERS, and magnetic solid phase microextraction ),as well as analytical methods (including chromatographic-mass spectrometric techniques, immunoassays, capillary electrophoresis, biosensors, and quantum dots -based approaches ). Comparative analysis reveals that accelerated solvent extraction (ASE ) and QuEChERS have emerged as mainstream pretreatment techniques owing to their high efficiency, automation, and environmental friendliness. Liquid chromatography-tandem mass spectrometry (LC-MS/MS ) remains the gold standard, due to its high sensitivity (limit of detection as low as 0.04 μg/kg ) and capability for simultaneous multi-residue determination (>100 compounds ). Meanwhile, electrochemical biosensors and molecularly imprinted polymer-based sensors demonstrate considerable potential for rapid on-site screening. Future research should aim to overcome current challenges such as complex matrix interference and accurate analysis of ultra-trace multi-residues, while promoting innovation in nanomaterial modification, multi-technology integration, and portable devices.
Publication Date
6-17-2026
First Page
233
Last Page
241
DOI
10.13652/j.spjx.1003.5788.2025.80918
Recommended Citation
Qiaoqiao, LUO; Yufeng, YUAN; Yunzhu, JIA; Qingya, CHEN; Fang, TAN; and Xin, ZHAO
(2026)
"Advances in extraction and detection technologies for veterinary drug residues in food,"
Food and Machinery: Vol. 42:
Iss.
5, Article 27.
DOI: 10.13652/j.spjx.1003.5788.2025.80918
Available at:
https://www.ifoodmm.cn/journal/vol42/iss5/27
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