•  
  •  
 

Abstract

Based on the theory of modern risk regulation and the existing research results at home and abroad, this paper discusses the bacteriophage as a kind of food antimicrobial agent from the perspective of risk assessment and risk regulation. In previous studies on risk assessment, no obvious adverse effects and side effects of phages on the environment, animals and human body were found. As an antibacterial agent, bacteriophage has shown good antibacterial effects in fruits and vegetables, meat, dairy products and seafood, with a very broad application prospect. However, while complying with the application research trend of bacteriophage food antimicrobial agents, it is necessary to face up to the possible risks of bacteriophage being used in large quantities, and conduct scientific and prudent risk regulation.

Publication Date

2-18-2023

First Page

12

Last Page

17

DOI

10.13652/j.issn.1003-5788.2020.10.003

References

[1] 魏麟,朱方莉,周洋,等.噬菌体在检测食源性病原菌中的应用研究进展[J].食品科学,2018,39(17):314-322.
[2] 赵冰,马国静.应用噬菌体保障即食食品安全的研究与分析[J].世界最新医学信息文摘,2018,18(40):203.
[3] AMMAR A M,ATTIA A M,EL-AZIZ N K A,et al.Class 1 integron and associated gene cassettes mediating multiple-drug resistance in some food borne pathogens[J].International Food Research Journal,2016,23(1):332-339.
[4] 任宏宇,李振,徐永平,等.应用噬菌体保障即食食品安全的研究进展[J].中国抗生素杂志,2017,42(9):731-736.
[5] 刘童,黄海燕,徐嘉良.噬菌体在食品安全领域的研究进展[J].食品科技,2015,40(8):296-300.
[6] WEINBAUER M G.Ecology of prokaryotic viruses[J].Fems Microbiology Reviews,2003,8(2):127-181.
[7] ALLWOOD P B,MALIK Y S,MAHERCHANDANI S,et al.Occurrence of Escherichia coli,noroviruses,and F-specific coliphages in fresh market-ready produce[J].J Food Prot,2004,67(11):2 387-2 390.
[8] ENDERSEN L,O'MAHONY J,HILL C,et al.Phage therapy in the food industry[J].Annual Review of Food Ence & Technology,2014,5(1):327.
[9] ANDRZEJ Górski,WEBER-DABROWSKA B.The potential role of endogenous bacteriophages in controlling invading pathogens[J].Cellular & Molecular Life Ences Cmls,2005,62(5):511.
[10] LIM E S,ZHOU Yan-jiao,ZHAO Guo-yan,et al.Early life dynamics of the human gut virome and bacterial microbiome in infants[J].Nature Medicine,2015,21(10):1 228-1 236.
[11] 丛聪,袁玉玉,王丽丽,等.噬菌体在食品应用中的安全性[J].国外医药(抗生素分册),2019,40(5):410-419.
[12] HWANG J Y,KIM J E,SONG Y J,et al.Safety of using Escherichia coli bacteriophages as a sanitizing agent based on inflammatory responses in rats[J].Food Ence & Biotechnology,2016,25(1):355-360.
[13] KISHOR C,MISHRA R R,SARAF S K,et al.Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model[J].Indian Journal of Medical Research,2016,143(1):87.
[14] DUENAS F,RIVERA D,TOLEDO V,et al.Short communication:Characterization of Salmonella phages from dairy calves on farms with history of diarrhea[J].Journal of Dairy Ence,2017,100(3):2 196-2 200.
[15] BRUTTIN A,BRUSSOW H.Human volunteers receiving Escherichia coli phage T4 orally:A safety test of phage therapy[J].Antimicrobial Agents & Chemotherapy,2005,49(7):2 874-2 878.
[16] MCCALLIN S,ALAM S S,BARRETTO C,et al.Safety analysis of a Russian phage cocktail:From metagenomic analysis to oral application in healthy human subjects[J].Virology,2013,443(2):187-196.
[17] SARKER S A,BERGER B,DENG Y,et al.Oral application of Escherichia coli bacteriophage:Safety tests in healthy and diarrheal children from bangladesh[J].Environmental Microbiology,2017,19(1):237-250.
[18] 韩晗,李雪敏,王爽,等.噬菌体作抗菌剂使用的安全性评价研究进展[J].江苏农业科学,2017,45(22):18-23.
[19] 吕阳,尹平,MOHAMED K M,等.噬菌体在食品安全控制中的研究进展[J].食品科学,2018,39(15):240-246.
[20] NICOLAS E G,JONATHAN L B,JAMES P R,et al.Bacteriophage cocktail reduces Salmonella enterica serovar Enteritidis counts in raw and smoked salmon tissues[J].Revista Argentina De Microbiología,2014,46(4):333-337.
[21] ENDERSEN L,COFFEY A,NEVE H,et al.Isolation and characterisation of six novel mycobacteriophages and investigation of their antimicrobial potential in milk[J].International Dairy Journal,2013,28(1):8-14.
[22] GUENTHER S,HUWYLER D,RICHARD S,et al.Virulent bacteriophage for efficient biocontrol of Listeria monocytogenes in ready-to-eat foods[J].Appl Environ Microbiol,2009,75(1):93-100.
[23] 李锦铨,黄晨曦,王小红.沙门氏菌噬菌体和噬菌体抗菌组合物及其应用:201610924016.0[P].2016-10-29.
[24] Bacteriophage P100 preparation from Listeria innocua:GRN No.198[EB/OL].(2006-10-17)[2020-09-18].https://www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=GRASNotices&id=198&sort=GRN_No&order=DESC&star trow=1&type=basic&search=198.2006.
[25] Bacteriophages LAND12,OLB1,TSRW1,DSMP1,DP1:GRN No.364[EB/OL].(2011-05-16)[2020-09-18].https://www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=GRASNotices&id=364&sort=GRN_No&order=DESC&startrow=1&type=basic&search=364.2011.
[26] Preparation consisting of six bacterial monophage specific to Salmonella enterica(monophage cocktail):GRN No.435[EB/OL].(2013-02-22)[2020-09-18].https://www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=GRASNotices&id=435&sort=GRN_No&order=DESC&startrow=1&typ e=basic&search=435.2013.
[27] Preparation containing five bacterial monophages specific to Shigella spp.:GRN No.672[EB/OL].(2017-03-27)[2020-09-18].https://www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=GRASNotices&id=672&sort=GRN_No&order=DESC&startrow=1&type=basic&search=672.2017.
[28] Preparation containing six bacterial phages specific to shiga-toxin producing Escherichia coli:GRN No.724[EB/OL].(2018-04-10)[2020-09-18].https://www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=GRASNotices&id=724&sort=GRN_No&order=DESC&startrow=1&type=basic&sear ch=724.2019.
[29] 欧元军.风险规制领域中科学原则探究:以食品安全标准制定为例[J].华东经济管理,2018,32(6):181-186.
[30] 安瑞.噬菌体治疗的前世、今生与未来:对话微生物学界噬菌体专家[J].科学通报,2017(23):2 577-2 580.
[31] 丁玉芳,生吉萍.中国转基因食品风险规制路径的选择[J].食品安全质量检测学报,2019,10(2):269-275.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.