A comprehensive analytical method based on high performance liquid chromatography (HPLC) was developed for measurement in foods of 6 phthalates-Dibutyl phthalate, Dioctyl Phthalate, Di-N-pentyl phthalate, Diethyl phthalate, Butyl benzyl phthalate, Diallyl phthalate. The extracts were analyzed by HPLC using an Inertsil C18 column. The two kind of organic mobile phases which are acetonitril and the methanol were compared. The acetonitril-water gradient elusion was found to be more advantageous. Under the optimal conditions, the calibration curves showed a good linearity (R2>0.999 0) in the concentration ranged from 1.0~20.0 mg/L for 4 target compounds. Recoveries of 6 analyses at three spiked levels ranged from 85.57% to 109.90%, with relative standard deviations (RSD) less than 10%. The detection limits of the method ranged from 0.179 to 0.425 mg/L. This method is sensitive and simple, and is suitable for the rapid determination of the phthalates added in the food.

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