In order to investigate the heating-release behaviour of heated tobacco products, powdered Virginia tobaccos were decomposed at the temperature of 150, 200, 250, 300, 350 and 400 ℃ by pyrolytic technology respectively. It was shown that total volatiles increased with the increasing heating temperature. Compared with burned tobacco, only 5 percent of nicotine was released at 200 ℃, while 62% and 82% at 200 and 250 ℃ respectively. The heating temperature had obvious effects on the release of nicotyrine, myosmine, cotinine and 2,3'-dipyridyl. The content of nicotyrine reached the highest level at 350 ℃, up to 15.68% of the released nicotine content at the same temperature. However,the nicotyrine delivered from burned tobacco was only 35% of released nicotyrine from the heated tobacco at 350 ℃. Cotinine showed the similar changing behavior to nicotyrine. The released myosmine increased quickly with increasing temperature, compared to the burned cigarette, reached 2.57%, 18.78%, 39.39%, 65.62%, 85.72% of the content of delivered myosmine respectively. Heated at below 250 ℃, the aromatic substances were vaporized and no harmful or potential harmful substances formed basically. With the elevated temperature, the harmful substances formed and increased with the increasing heated temperature. The main harmful or potential harmful substances included phenol, methyl phenol, ethyl phenol, hydroquinone, 1,2-benzenediol, benzofuran derivatives, benzyl nitrile and benzenepropanenitrile.

Publication Date


First Page


Last Page





[1] Ralf Zimmermann, Romy Hertz-Schünemann, Sven Ehlert, et al. Highly time-resolved imaging of combustion and pyrolysis product concentrations in solid fuel combustion: no formation in a burning cigarette[J]. Analytical Chemistry, 2015, 87(3):1 711~1 717.
[2] Chris Moyses, Alex Hearn, Andrew Redfern. Evaluation of a novel nicotine inhaler device: part 1-arterial and venous pharmacokinetics[J]. Nicotine and Tobacco Research, 2015, 17(1): 18~25.
[3] Dietrich Hoffmann, Ilse Hoffmann, Karam El-Bayoumy. The less harmful cigarette: a controversial issue. a tribute to ernst l. wynder[J]. Chemical Research in Toxicology, 2001, 14(7): 767~790.
[4] Cheryl A Oncken, Mark D Litt, Lynn D McLaughlin, et al. Nicotine concentrations with electronic cigarette use: effects of sex and flavor[J]. Nicotine and Tobacco Research, 2015, 17(4): 473~478.
[5] Barbara Davis, Michael Dang, Jisoo Kim, et al. Nicotine concentrations in electronic cigarette refill and do-it-yourself fluids[J]. Nicotine and Tobacco Research, 2015, 17(2): 134~141.
[6] Christine L Megerdichian, Vaughan W Rees, Geoffrey Ferris Wayne, et al. Internal tobacco industry research on olfactory and trigeminal nerve response to nicotine and other smoke components[J]. Nicotine and Tobacco Research, 2007, 9(11): 1 119~1 129.
[7] Fiammetta Cosci, Kenneth Abrams, Koen R J Schruers, et al. Effect of Nicotine on 35% CO2-Induced anxiety: a study in healthy volunteers[J]. Nicotine and Tobacco Research, 2006, 8(4): 511~517.
[8] Tara Parker-Pope. "Safer" cigarettes: a history. (2001—10—02)[2015—01—30]. http://www.pbs.org/wgbh/nova/body/safer-cigarettes-history.html.
[9] Richard R Baker, Louise J Bishop. The pyrolysis of tobacco ingredients[J]. Journal of Analytical and Applied Pyrolysis, 2004, 71(1): 223~311.
[10] 罗昌荣,谢焰,印黔黔. 葡萄糖、果糖和蔗糖/脯氨酸的共裂解行为研究[J].烟草科技, 2014(2): 61~69.
[11] David G Gilbert, Chihiro Sugai, Zuo Yan-tao, et al. Effects of nicotine on brain responses to emotional pictures[J]. Nicotine and Tobacco Research, 2004, 6(6): 985~996.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.