Based on the numerical simulation method on computational fluid dynamics (Computational fluid dynamics, CFD), and using anion exchange resin (717) as internal chromatography media, the fluid distribution and flow resistance characteristics in ion exchange column were studied respectively. For the convenience of simulation, water was selected as feed liquid, at the flow rate of 3 m3/h, appeared laminar flow state in the exchange column. On the assumption that the fluid uniform premise, the flow resistance characteristics for the column ion exchange resin filler was simulated by the two-dimensional porous media model, and the effects of the exchange column of fluid pressure drop on different working conditions and structure. Taking the ion exchange column head distributor as the research object, the fluid distribution of the chromatography column was simulated. According to the simulation results, distributor configuration was improved to achieve a uniform distribution of fluid to some extent, which could offer system supporter for the next system building and simulation, and further provide theoretical foundation and model support for structure optimization and engineering enlargement for the design of new ion exchange column.

Publication Date


First Page


Last Page





[1] 王峰, 闫清东, 马越, 等. 基于CFD技术的液力减速器性能预测研究[J]. 系统仿真学报, 2007, 19(3): 1 390~1 396.
[2] 王福军. 计算流体动力学分析—CFD 软件原理与应用[M]. 北京: 清华大学出版社, 2004.
[3] 高富东, 姜乐华, 潘存云. 基于计算流体动力学的两栖车辆水动力特性数值计算[J]. 机械工程学报, 2009, 45(5): 134~139.
[4] 张少坤,尹侠. 双层桨搅拌槽内流场的数值模拟[J]. 食品与机械, 2011, 27(1):71~73.
[5] 蔡子金,李军庆,张庆文,等. CFD在搅拌罐性能研究和生化过程放大中的应用[J]. 食品与机械,2013,29(6):108~112.
[6] 陈文礼, 李惠. 基于RANS的圆柱风致涡激振动的CFD数值模拟[J]. 西安建筑科技大学学报(自然科学版),2006, 38(4): 509~513.
[7] 周宛平.化学分离法[M]. 北京:北京大学出版社,2008:127.
[8] 林炳昌. 模拟移动床色谱技术[M]. 北京: 化学工业出版社, 2008:37~44.
[9] 吴献东, 金晓明, 徐志成, 等. 微粒群算法在模拟移动床色谱分离过程优化中的应用[J].化工自动化及仪表, 2006, 33(4): 5~8.
[10] 吴献东, 金晓明, 苏宏业. 基于NSGA-Ⅱ的模拟移动床色谱分离过程多目标操作优化[J].化工学报, 2007, 58(8): 2 038~2 044.
[11] Kurup A S, Hidajat K, Ray A K. Optimal operation of an industrial-scale Parex process for the recovery of p-xylene from a mixture of C8 aromatics[J]. Industrial & Engineering Chemistry Research, 2005, 44 (15): 5 703~5 714.
[12] Subramani H J, Hidajat K, Ray A K. Optimization of simulated moving bed and varicol process forglucose-fructose separation[J]. Chemical Engineering Research and Design, 2003, 81(5): 549~567.

Included in

Food Science Commons



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.